Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study
BackgroundDyslipidemia is closely related to diabetic neuropathy. This study examined the potential causal relationship involving 179 lipid species and the disease.MethodsThe pooled data on 179 lipid species and diabetic neuropathy were obtained from previous genome-wide association studies (GWAS)....
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1398691/full |
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| author | Zhaoxiang Wang Zhong Liu Qichao Yang Qichao Yang Huibo Qiao Huibo Qiao Yong Yin Yong Yin Zhiyong Zhao Zhiyong Zhao Xuejing Shao Xuejing Shao |
| author_facet | Zhaoxiang Wang Zhong Liu Qichao Yang Qichao Yang Huibo Qiao Huibo Qiao Yong Yin Yong Yin Zhiyong Zhao Zhiyong Zhao Xuejing Shao Xuejing Shao |
| author_sort | Zhaoxiang Wang |
| collection | DOAJ |
| description | BackgroundDyslipidemia is closely related to diabetic neuropathy. This study examined the potential causal relationship involving 179 lipid species and the disease.MethodsThe pooled data on 179 lipid species and diabetic neuropathy were obtained from previous genome-wide association studies (GWAS). A Mendelian Randomization (MR) method was employed to investigate the potential causal link, and the robustness of the findings was confirmed through comprehensive sensitivity analyses.ResultsGenetically, phosphatidylcholine might be associated with the risk of diabetic neuropathy. Upon adjusting for multiple comparisons, higher levels of phosphatidylcholine (16:0_20:2) (OR = 0.82, 95%CI: 0.73-0.91; P < 0.001, FDR = 0.033) and phosphatidylcholine (16:1_18:1) (OR = 0.77, 95%CI: 0.67-0.88; P < 0.001, FDR = 0.019) are associated with a decreased risk of diabetic neuropathy. Further multivariable MR (MVMR) analysis demonstrated the effect of genetically predicted phosphatidylcholine (16:1_18:1) remained after adjusting for body mass index (BMI) and glycated hemoglobin (HbA1c). Sensitivity assessments have confirmed the robustness of these findings, revealing no evidence of heterogeneity or pleiotropy.ConclusionOur research linked certain lipid species with diabetic neuropathy risk, suggesting that targeting lipids could be a therapeutic strategy in clinical trials addressing this condition. |
| format | Article |
| id | doaj-art-0759872c77504ebcb55acfa5634ff527 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-0759872c77504ebcb55acfa5634ff5272025-01-15T05:10:24ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.13986911398691Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization studyZhaoxiang Wang0Zhong Liu1Qichao Yang2Qichao Yang3Huibo Qiao4Huibo Qiao5Yong Yin6Yong Yin7Zhiyong Zhao8Zhiyong Zhao9Xuejing Shao10Xuejing Shao11Department of Endocrinology, First People’s Hospital of Kunshan, Kunshan, Jiangsu, ChinaDepartment of Emergency Medicine, First People’s Hospital of Kunshan, Kunshan, Jiangsu, ChinaDepartment of Endocrinology, Affiliated Wujin Hospital of Jiangsu University, Changzhou, Jiangsu, ChinaDepartment of Endocrinology, Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, ChinaDepartment of Endocrinology, Affiliated Wujin Hospital of Jiangsu University, Changzhou, Jiangsu, ChinaDepartment of Endocrinology, Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, ChinaDepartment of Endocrinology, Affiliated Wujin Hospital of Jiangsu University, Changzhou, Jiangsu, ChinaDepartment of Endocrinology, Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, ChinaDepartment of Endocrinology, Affiliated Wujin Hospital of Jiangsu University, Changzhou, Jiangsu, ChinaDepartment of Endocrinology, Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, ChinaDepartment of Endocrinology, Affiliated Wujin Hospital of Jiangsu University, Changzhou, Jiangsu, ChinaDepartment of Endocrinology, Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, ChinaBackgroundDyslipidemia is closely related to diabetic neuropathy. This study examined the potential causal relationship involving 179 lipid species and the disease.MethodsThe pooled data on 179 lipid species and diabetic neuropathy were obtained from previous genome-wide association studies (GWAS). A Mendelian Randomization (MR) method was employed to investigate the potential causal link, and the robustness of the findings was confirmed through comprehensive sensitivity analyses.ResultsGenetically, phosphatidylcholine might be associated with the risk of diabetic neuropathy. Upon adjusting for multiple comparisons, higher levels of phosphatidylcholine (16:0_20:2) (OR = 0.82, 95%CI: 0.73-0.91; P < 0.001, FDR = 0.033) and phosphatidylcholine (16:1_18:1) (OR = 0.77, 95%CI: 0.67-0.88; P < 0.001, FDR = 0.019) are associated with a decreased risk of diabetic neuropathy. Further multivariable MR (MVMR) analysis demonstrated the effect of genetically predicted phosphatidylcholine (16:1_18:1) remained after adjusting for body mass index (BMI) and glycated hemoglobin (HbA1c). Sensitivity assessments have confirmed the robustness of these findings, revealing no evidence of heterogeneity or pleiotropy.ConclusionOur research linked certain lipid species with diabetic neuropathy risk, suggesting that targeting lipids could be a therapeutic strategy in clinical trials addressing this condition.https://www.frontiersin.org/articles/10.3389/fendo.2024.1398691/fulllipidsdiabetic neuropathyGWASMendelian randomization analysiscausal relationship |
| spellingShingle | Zhaoxiang Wang Zhong Liu Qichao Yang Qichao Yang Huibo Qiao Huibo Qiao Yong Yin Yong Yin Zhiyong Zhao Zhiyong Zhao Xuejing Shao Xuejing Shao Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study Frontiers in Endocrinology lipids diabetic neuropathy GWAS Mendelian randomization analysis causal relationship |
| title | Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study |
| title_full | Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study |
| title_fullStr | Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study |
| title_full_unstemmed | Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study |
| title_short | Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study |
| title_sort | causal relationships between plasma lipidome and diabetic neuropathy a mendelian randomization study |
| topic | lipids diabetic neuropathy GWAS Mendelian randomization analysis causal relationship |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1398691/full |
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