Nanomaterials at the forefront of antimicrobial therapy by photodynamic and photothermal strategies
In the face of the increasing resistance of microorganisms to traditional antibiotics, the development of innovative treatment methods is becoming increasingly urgent. Nanophototherapy technology can precisely target the infected area and achieve synergistic antibacterial effects in multiple modes....
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004150 |
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| author | Ling Mei Yifan Zhang Kaixi Wang Sijing Chen Tao Song |
| author_facet | Ling Mei Yifan Zhang Kaixi Wang Sijing Chen Tao Song |
| author_sort | Ling Mei |
| collection | DOAJ |
| description | In the face of the increasing resistance of microorganisms to traditional antibiotics, the development of innovative treatment methods is becoming increasingly urgent. Nanophototherapy technology can precisely target the infected area and achieve synergistic antibacterial effects in multiple modes. This phototherapy method has shown significant efficacy in treating diseases caused by drug-resistant bacteria, especially in the elimination of biofilms, where it has demonstrated strong dissolution capabilities. PTT utilizes photothermal agents to convert near-infrared light into heat, effectively killing bacteria and promoting tissue regeneration. Similarly, PDT utilizes photosensitizers, which produce reactive oxygen species (ROS) when activated by light, destroying the structure and function of bacterial cells. This review summarizes photothermal agents and photosensitizers used for antibacterial purposes. In conducting our literature review, we employed a systematic approach to ensure a comprehensive and representative selection of studies. Additionally, this article explores the potential of phototherapy in regulating wound microenvironments, promoting wound healing, and activating the immune system. Nanophototherapeutic materials show great potential for application in antibacterial treatment and are expected to provide innovative solutions for drug-resistant bacterial infections that traditional antibiotics are struggling to address. |
| format | Article |
| id | doaj-art-0758b13aa7084f2fbef69079b252802b |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-0758b13aa7084f2fbef69079b252802b2025-08-20T02:37:39ZengElsevierMaterials Today Bio2590-00642024-12-012910135410.1016/j.mtbio.2024.101354Nanomaterials at the forefront of antimicrobial therapy by photodynamic and photothermal strategiesLing Mei0Yifan Zhang1Kaixi Wang2Sijing Chen3Tao Song4Engineering Research Center for Pharmaceuticals and Equipments of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, ChinaEngineering Research Center for Pharmaceuticals and Equipments of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, ChinaEngineering Research Center for Pharmaceuticals and Equipments of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, ChinaSichuan Electric Power Hospital, Chengdu, Sichuan Province, ChinaEngineering Research Center for Pharmaceuticals and Equipments of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, China; Corresponding author.In the face of the increasing resistance of microorganisms to traditional antibiotics, the development of innovative treatment methods is becoming increasingly urgent. Nanophototherapy technology can precisely target the infected area and achieve synergistic antibacterial effects in multiple modes. This phototherapy method has shown significant efficacy in treating diseases caused by drug-resistant bacteria, especially in the elimination of biofilms, where it has demonstrated strong dissolution capabilities. PTT utilizes photothermal agents to convert near-infrared light into heat, effectively killing bacteria and promoting tissue regeneration. Similarly, PDT utilizes photosensitizers, which produce reactive oxygen species (ROS) when activated by light, destroying the structure and function of bacterial cells. This review summarizes photothermal agents and photosensitizers used for antibacterial purposes. In conducting our literature review, we employed a systematic approach to ensure a comprehensive and representative selection of studies. Additionally, this article explores the potential of phototherapy in regulating wound microenvironments, promoting wound healing, and activating the immune system. Nanophototherapeutic materials show great potential for application in antibacterial treatment and are expected to provide innovative solutions for drug-resistant bacterial infections that traditional antibiotics are struggling to address.http://www.sciencedirect.com/science/article/pii/S2590006424004150NanomaterialsPhotothermal therapyPhotodynamic therapyAntimicrobial therapy |
| spellingShingle | Ling Mei Yifan Zhang Kaixi Wang Sijing Chen Tao Song Nanomaterials at the forefront of antimicrobial therapy by photodynamic and photothermal strategies Materials Today Bio Nanomaterials Photothermal therapy Photodynamic therapy Antimicrobial therapy |
| title | Nanomaterials at the forefront of antimicrobial therapy by photodynamic and photothermal strategies |
| title_full | Nanomaterials at the forefront of antimicrobial therapy by photodynamic and photothermal strategies |
| title_fullStr | Nanomaterials at the forefront of antimicrobial therapy by photodynamic and photothermal strategies |
| title_full_unstemmed | Nanomaterials at the forefront of antimicrobial therapy by photodynamic and photothermal strategies |
| title_short | Nanomaterials at the forefront of antimicrobial therapy by photodynamic and photothermal strategies |
| title_sort | nanomaterials at the forefront of antimicrobial therapy by photodynamic and photothermal strategies |
| topic | Nanomaterials Photothermal therapy Photodynamic therapy Antimicrobial therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004150 |
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