Induced protein expression in Leptospira spp. and its application to CRISPR/Cas9 mutant generation

Induced protein expression in Leptospira spp. and its application to CRISPR/Cas9 mutant generation

Abstract Expanding the genetic toolkit for Leptospira spp. is a crucial step toward advancing our understanding of the biology and virulence of these atypical bacteria. Pathogenic Leptospira are responsible for over 1 million human leptospirosis cases annually and significantly impact domestic anima...

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Bibliographic Details
Main Authors: L. G. V. Fernandes, A. L. T. O. Nascimento, J. E. Nally
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
IPTG
Mutagenesis
Leptospira
Knockdown
dCas9
Knockout
Online Access:https://doi.org/10.1038/s41598-025-88633-w
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