Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1<i>H</i>-1,2,3-triazoles: A Review of Their Anticancer Activity
Despite multiple advances in treatment and prevention, cancer remains one of the leading causes of death worldwide. Chemotherapy remains the most effective method for cancer treatment. However, commercial chemotherapeutic drugs have limited efficacy, severe side effects, and acquired resistance. The...
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MDPI AG
2024-11-01
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| author | Delia Hernández-Romero Sharon Rosete-Luna Enrique Méndez-Bolaina Elena de la C. Herrera-Cogco Luis P. Amador-Gómez Anell Soto-Contreras José M. Rivera-Villanueva Raúl Colorado-Peralta |
| author_facet | Delia Hernández-Romero Sharon Rosete-Luna Enrique Méndez-Bolaina Elena de la C. Herrera-Cogco Luis P. Amador-Gómez Anell Soto-Contreras José M. Rivera-Villanueva Raúl Colorado-Peralta |
| author_sort | Delia Hernández-Romero |
| collection | DOAJ |
| description | Despite multiple advances in treatment and prevention, cancer remains one of the leading causes of death worldwide. Chemotherapy remains the most effective method for cancer treatment. However, commercial chemotherapeutic drugs have limited efficacy, severe side effects, and acquired resistance. Therefore, the scientific community has devoted a great effort to designing new, more effective, and cheaper drugs. In this sense, copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) provide 1,4-disubstituted 1<i>H</i>-1,2,3-triazoles in high yields without forming by-products. This reaction allows the easy, efficient, functional, ordered, rapid, selective, and specific joining of small molecules, giving rise to more complex molecules. The CuACC reaction simplifies the synthesis processes, accelerating the discovery of new chemotherapeutic agents by allowing the joining of commercial platinum drugs, slightly altering their structure, or creating new molecules with improved properties. This work shows the importance of CuAAC reactions in the search for new metallodrugs with possible anticancer activity. |
| format | Article |
| id | doaj-art-0750ec6033074265bc17880930cfabe3 |
| institution | OA Journals |
| issn | 2624-781X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reactions |
| spelling | doaj-art-0750ec6033074265bc17880930cfabe32025-08-20T02:01:09ZengMDPI AGReactions2624-781X2024-11-015494798310.3390/reactions5040050Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1<i>H</i>-1,2,3-triazoles: A Review of Their Anticancer ActivityDelia Hernández-Romero0Sharon Rosete-Luna1Enrique Méndez-Bolaina2Elena de la C. Herrera-Cogco3Luis P. Amador-Gómez4Anell Soto-Contreras5José M. Rivera-Villanueva6Raúl Colorado-Peralta7Facultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, Orizaba C.P., Veracruz 94340, MexicoFacultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, Orizaba C.P., Veracruz 94340, MexicoFacultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, Orizaba C.P., Veracruz 94340, MexicoFacultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, Orizaba C.P., Veracruz 94340, MexicoFacultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, Orizaba C.P., Veracruz 94340, MexicoFacultad de Ciencias Biológicas y Agropecuarias, Universidad Veracruzana, Calle Josefa Ortiz y Domínguez, Camino Peñuela-Amatlán S/N, Amatlán de los Reyes C.P., Veracruz 94500, MexicoFacultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, Orizaba C.P., Veracruz 94340, MexicoFacultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, Orizaba C.P., Veracruz 94340, MexicoDespite multiple advances in treatment and prevention, cancer remains one of the leading causes of death worldwide. Chemotherapy remains the most effective method for cancer treatment. However, commercial chemotherapeutic drugs have limited efficacy, severe side effects, and acquired resistance. Therefore, the scientific community has devoted a great effort to designing new, more effective, and cheaper drugs. In this sense, copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) provide 1,4-disubstituted 1<i>H</i>-1,2,3-triazoles in high yields without forming by-products. This reaction allows the easy, efficient, functional, ordered, rapid, selective, and specific joining of small molecules, giving rise to more complex molecules. The CuACC reaction simplifies the synthesis processes, accelerating the discovery of new chemotherapeutic agents by allowing the joining of commercial platinum drugs, slightly altering their structure, or creating new molecules with improved properties. This work shows the importance of CuAAC reactions in the search for new metallodrugs with possible anticancer activity.https://www.mdpi.com/2624-781X/5/4/50CuAAC reactionclick chemistry1,2,3-triazolescycloadditionplatinum complexesanticancer activity |
| spellingShingle | Delia Hernández-Romero Sharon Rosete-Luna Enrique Méndez-Bolaina Elena de la C. Herrera-Cogco Luis P. Amador-Gómez Anell Soto-Contreras José M. Rivera-Villanueva Raúl Colorado-Peralta Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1<i>H</i>-1,2,3-triazoles: A Review of Their Anticancer Activity Reactions CuAAC reaction click chemistry 1,2,3-triazoles cycloaddition platinum complexes anticancer activity |
| title | Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1<i>H</i>-1,2,3-triazoles: A Review of Their Anticancer Activity |
| title_full | Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1<i>H</i>-1,2,3-triazoles: A Review of Their Anticancer Activity |
| title_fullStr | Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1<i>H</i>-1,2,3-triazoles: A Review of Their Anticancer Activity |
| title_full_unstemmed | Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1<i>H</i>-1,2,3-triazoles: A Review of Their Anticancer Activity |
| title_short | Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1<i>H</i>-1,2,3-triazoles: A Review of Their Anticancer Activity |
| title_sort | importance of the cuaac reaction in the synthesis of platinum complexes with 1 4 disubstituted 1 i h i 1 2 3 triazoles a review of their anticancer activity |
| topic | CuAAC reaction click chemistry 1,2,3-triazoles cycloaddition platinum complexes anticancer activity |
| url | https://www.mdpi.com/2624-781X/5/4/50 |
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