Inhibition of 5-Lipoxygenase Pathway Attenuates Acute Liver Failure by Inhibiting Macrophage Activation

Inhibition of 5-Lipoxygenase Pathway Attenuates Acute Liver Failure by Inhibiting Macrophage Activation

This study aimed to investigate the role of 5-lipoxygenase (5-LO) in acute liver failure (ALF) and changes in macrophage activation by blocking it. ALF was induced in rats by administration of D-galactosamine (D-GalN)/lipopolysaccharide (LPS). Rats were injected intraperitoneally with AA-861 (a spec...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lu Li, Yi-Rong Liu, Shan Gao, Jun-Feng Li, Shan-Shan Li, Dan-Dan Zhang, Shuang Liu, Li Bai, Su-Jun Zheng, Zhong-Ping Duan, Min Qi, Yu Chen
Format:	Article
Language:	English
Published:	Wiley 2014-01-01
Series:	Journal of Immunology Research
Online Access:	http://dx.doi.org/10.1155/2014/697560
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Inhibition RIP1 prevents acute liver failure by suppressing hepatic apoptosis and attenuating the secretion of TNF-α from macrophages
by: Aichun Li, et al.
Published: (2025-07-01)

15-Lipoxygenase-2 deficiency induces foam cell formation that can be restored by salidroside through the inhibition of arachidonic acid effects
by: Huang Rong, et al.
Published: (2025-04-01)

Pharmacological inhibition of key metabolic pathways attenuates Leishmania spp infection in macrophages.
by: Elaine Carvalho de Oliveira, et al.
Published: (2025-01-01)

Extraction of total flavonoids from Chaenomeles speciosa (Sweet) Nakai and its antioxidant and lipoxygenase inhibition effects.
by: Wenqing Pei, et al.
Published: (2025-01-01)

Eosinophils and pleural macrophages counter regulate IL-33-elicited airway inflammation via the 12/15-lipoxygenase pathway
by: Emi Ito, et al.
Published: (2025-04-01)

IL‐38 attenuates myocardial ischemia–reperfusion injury by inhibiting macrophage inflammation
by: Yuzhen Wei, et al.
Published: (2023-06-01)

Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling
by: Dan Wang, et al.
Published: (2025-06-01)

Liver macrophage-derived exosomal miRNA-342-3p promotes liver fibrosis by inhibiting HPCAL1 in stellate cells
by: Wenshuai Li, et al.
Published: (2025-02-01)

Fludarabine attenuates inflammation and dysregulated autophagy in alveolar macrophages via inhibition of STAT1/IRF1 pathway
by: Jooyeon Lee, et al.
Published: (2025-05-01)

Fractionation of an ethanolic extract of purple leaves (Graptophyllum pictum) with antioxidant and lipoxygenase activity inhibition assay
by: Feda Anisah Makkiyah, et al.
Published: (2025-01-01)

Smad4 deficiency in hepatocytes attenuates NAFLD progression via inhibition of lipogenesis and macrophage polarization
by: Wei Yang, et al.
Published: (2025-01-01)

Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats
by: Peng Li, et al.
Published: (2016-01-01)

M2-like macrophage-derived exosomes inhibit osteoclastogenesis via releasing miR-1227-5p
by: Shan Chen, et al.
Published: (2025-01-01)

The Acute Phase of Trypanosoma cruzi Infection Is Attenuated in 5-Lipoxygenase-Deficient Mice
by: Adriana M. C. Canavaci, et al.
Published: (2014-01-01)

the lipoxygenase Estimating Lipoxygenase and Gamma-glutamyl Transferase Activities in Sera of Colon Cancer Patients with Partial Purification of Lipoxygenase
by: Al-Adlee et al.
Published: (2020-05-01)

Exploring the Anti-Inflammatory Potential of Ajuga integrifolia Leaves Extract: In Vitro Dual Inhibition of Cyclooxygenase and Lipoxygenase Enzymes
by: Sisay Awoke Endalew, et al.
Published: (2024-01-01)

Ebosin Attenuates the Inflammatory Responses Induced by TNF-α through Inhibiting NF-κB and MAPK Pathways in Rat Fibroblast-Like Synoviocytes
by: Yang Zhang, et al.
Published: (2022-01-01)

S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling
by: Wenyi Cai, et al.
Published: (2025-04-01)

Nanoparticle-mediated SIRT1 inhibition suppresses M2 macrophage polarization and hepatocarcinogenesis in chronic hepatitis B
by: He Zhang, et al.
Published: (2025-05-01)

Major Vault Protein in Macrophages Reprograms Immune Microenvironment and Inhibits Occurrence and Development of Liver Cancer
by: Shimeng ZHOU, et al.
Published: (2025-02-01)

mRNA-103 inhibition attenuates autophagy and inflammation in myocardial infarction by regulating the TLR4 pathway
by: Fan Li, et al.
Published: (2020-02-01)

AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-κB Pathway to Attenuate Liver Injury and Fibrosis in BDL Rats
by: Haoyang Zhu, et al.
Published: (2018-01-01)

Mdivi-1 Attenuates Sepsis-Associated Acute Lung Injury by Inhibiting M1 Alveolar Macrophage Polarization and Pyroptosis
by: Xiaoyu Zhang, et al.
Published: (2025-01-01)

Decoding the genome of SARS-CoV-2: a pathway to drug development through translation inhibition
by: Shan-Na Wu, et al.
Published: (2024-12-01)

STING modulates HBV-related acute-on-chronic liver failure by mediating autophagy and macrophage polarization
by: Hao Zhang, et al.
Published: (2025-01-01)

Kaempferol inhibits oxidative stress and reduces macrophage pyroptosis by activating the NRF2 signaling pathway
by: Yu Wang, et al.
Published: (2025-01-01)

Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition
by: Jing-Jing Liu, et al.
Published: (2025-06-01)

RETRACTED: Calycosin inhibits hepatocyte apoptosis in acute liver failure by suppressing the TLR4/NF‐κB pathway: An in vitro study
by: Le Chang, et al.
Published: (2023-07-01)

SFRP1 suppresses granulosa cell proliferation and migration through inhibiting JNK pathway
by: Shan Zhou, et al.
Published: (2021-10-01)

Correction: S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling
by: Wenyi Cai, et al.
Published: (2025-04-01)

Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway
by: Tingting Zhang, et al.
Published: (2025-02-01)

Atorvastatin Attenuates Endothelial Cell Injury in Atherosclerosis Through Inhibiting ACSL4-Mediated Ferroptosis
by: Huilian Tan, et al.
Published: (2024-01-01)

IL-33-Pretreated Mesenchymal Stem Cells Attenuate Acute Liver Failure by Improving Homing and Polarizing M2 Macrophages
by: Hui Yuan, et al.
Published: (2024-01-01)

GSK-3β Inhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis
by: Hui Zhang, et al.
Published: (2014-01-01)

Inhibition of hedgehog pathway reveals the regulatory role of SMO in gastric cancer cells
by: Zixin Yang, et al.
Published: (2017-06-01)

Wenqing Yin Attenuates the Allergic Contact Dermatitis Response by Inhibiting the JAK2/STAT1 and MAPK Signaling Pathways
by: Ren M, et al.
Published: (2025-05-01)

Anti-Inflammatory Peptide Prevents Aβ<sub>25–35</sub>-Induced Inflammation in Rats via Lipoxygenase Inhibition
by: Yudhishthir Yadav, et al.
Published: (2025-06-01)

Atractylenolide I Inhibits Nicotine-Induced Macrophage Pyroptosis and Alleviates Atherogenesis by Suppressing the TLR4/ROS/TXNIP/NLRP3 Pathway
by: Huan-Huan Li, et al.
Published: (2025-05-01)

Inhibition of Rho GEFs attenuates pulmonary fibrosis through suppressing myofibroblast activation and reprogramming profibrotic macrophages
by: Chengju Luo, et al.
Published: (2025-04-01)

Knockout of macrophage Zfp260 attenuates periodontitis in mice via inhibiting M1-type polarization
by: XIONG Jin, et al.
Published: (2024-08-01)