The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases
Recent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually r...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2011.132 |
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| author | Simon J. Conway Thomas Doetschman Mohamad Azhar |
| author_facet | Simon J. Conway Thomas Doetschman Mohamad Azhar |
| author_sort | Simon J. Conway |
| collection | DOAJ |
| description | Recent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases. |
| format | Article |
| id | doaj-art-074f0fc1c6334fffaed1763034566cc2 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-074f0fc1c6334fffaed1763034566cc22025-02-03T01:11:49ZengWileyThe Scientific World Journal1537-744X2011-01-01111509152410.1100/tsw.2011.132The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart DiseasesSimon J. Conway0Thomas Doetschman1Mohamad Azhar2Riley Heart Research Center, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USABIO5 Institute, University of Arizona, Tucson, USABIO5 Institute, University of Arizona, Tucson, USARecent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.http://dx.doi.org/10.1100/tsw.2011.132 |
| spellingShingle | Simon J. Conway Thomas Doetschman Mohamad Azhar The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases The Scientific World Journal |
| title | The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases |
| title_full | The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases |
| title_fullStr | The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases |
| title_full_unstemmed | The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases |
| title_short | The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases |
| title_sort | inter relationship of periostin tgfβ and bmp in heart valve development and valvular heart diseases |
| url | http://dx.doi.org/10.1100/tsw.2011.132 |
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