Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study
Abstract Background Epidemiological and other studies have shown correlations among major depressive disorder (MDD), anxiety disorder (AXD) and constipation. However, no consensus has been reached regarding their interdependence and pathogenesis. Herein, we sought to further explore the causal assoc...
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BMC
2024-11-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-024-03526-y |
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| author | ZhiYu Deng XiaoYu Zeng HanYu Wang Wei Bi YuMei Huang Hao Fu |
| author_facet | ZhiYu Deng XiaoYu Zeng HanYu Wang Wei Bi YuMei Huang Hao Fu |
| author_sort | ZhiYu Deng |
| collection | DOAJ |
| description | Abstract Background Epidemiological and other studies have shown correlations among major depressive disorder (MDD), anxiety disorder (AXD) and constipation. However, no consensus has been reached regarding their interdependence and pathogenesis. Herein, we sought to further explore the causal associations between them. Methods Bidirectional two-sample Mendelian randomization (MR) analysis was performed to confirm the causal link between MDD, AXD and constipation. Genetic instrumental variables for MDD, AXD, and constipation were obtained from publicly available genome-wide association studies (GWASs). In this MR analysis, inverse variance weighting (IVW) was used as the primary analysis method to evaluate the causal effect. Additionally, we employed Cochran’s Q test, MR‒Egger intercept and MR-PRESSO analysis to examine heterogeneity and pleiotropy. Moreover, leave-one-out analysis was employed to investigate the stability of the associations. Finally, a reverse analysis of Mendelian randomization was conducted. Results The results revealed a causal relationship between MDD and an increased risk of constipation (p = 0.0001), whereas AXD (p = 8.52 × 10–1) did not increase the risk of constipation. In the inverse MR analysis, no causal associations were found (constipation to MDD: p = 9.37 × 10–1; constipation to AXD: p = 8.51 × 10–1). Conclusion This MR study revealed genetic evidence supporting a causal relationship between MDD and constipation. |
| format | Article |
| id | doaj-art-074e42e5e5314f55a73f63b2497d49da |
| institution | OA Journals |
| issn | 1471-230X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-074e42e5e5314f55a73f63b2497d49da2025-08-20T02:08:23ZengBMCBMC Gastroenterology1471-230X2024-11-012411810.1186/s12876-024-03526-yCausal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization studyZhiYu Deng0XiaoYu Zeng1HanYu Wang2Wei Bi3YuMei Huang4Hao Fu5Clinical Medical College, Chengdu University of Traditional Chinese MedicineClinical Medical College, Chengdu University of Traditional Chinese MedicineClinical Medical College, Chengdu University of Traditional Chinese MedicineClinical Medical College, Chengdu University of Traditional Chinese MedicineClinical Medical College, Chengdu University of Traditional Chinese MedicineClinical Medical College, Chengdu University of Traditional Chinese MedicineAbstract Background Epidemiological and other studies have shown correlations among major depressive disorder (MDD), anxiety disorder (AXD) and constipation. However, no consensus has been reached regarding their interdependence and pathogenesis. Herein, we sought to further explore the causal associations between them. Methods Bidirectional two-sample Mendelian randomization (MR) analysis was performed to confirm the causal link between MDD, AXD and constipation. Genetic instrumental variables for MDD, AXD, and constipation were obtained from publicly available genome-wide association studies (GWASs). In this MR analysis, inverse variance weighting (IVW) was used as the primary analysis method to evaluate the causal effect. Additionally, we employed Cochran’s Q test, MR‒Egger intercept and MR-PRESSO analysis to examine heterogeneity and pleiotropy. Moreover, leave-one-out analysis was employed to investigate the stability of the associations. Finally, a reverse analysis of Mendelian randomization was conducted. Results The results revealed a causal relationship between MDD and an increased risk of constipation (p = 0.0001), whereas AXD (p = 8.52 × 10–1) did not increase the risk of constipation. In the inverse MR analysis, no causal associations were found (constipation to MDD: p = 9.37 × 10–1; constipation to AXD: p = 8.51 × 10–1). Conclusion This MR study revealed genetic evidence supporting a causal relationship between MDD and constipation.https://doi.org/10.1186/s12876-024-03526-yMendelian randomizationMajor depressive disorderAnxiety disorderConstipationGWAS |
| spellingShingle | ZhiYu Deng XiaoYu Zeng HanYu Wang Wei Bi YuMei Huang Hao Fu Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study BMC Gastroenterology Mendelian randomization Major depressive disorder Anxiety disorder Constipation GWAS |
| title | Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study |
| title_full | Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study |
| title_fullStr | Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study |
| title_full_unstemmed | Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study |
| title_short | Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study |
| title_sort | causal relationship between major depressive disorder anxiety disorder and constipation a two sample mendelian randomization study |
| topic | Mendelian randomization Major depressive disorder Anxiety disorder Constipation GWAS |
| url | https://doi.org/10.1186/s12876-024-03526-y |
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