Preexisting ulcerative colitis increases the risk of immune-related colitis and predicts divergent survival outcomes in gastrointestinal cancer patients treated with immune checkpoint inhibitors

Preexisting ulcerative colitis increases the risk of immune-related colitis and predicts divergent survival outcomes in gastrointestinal cancer patients treated with immune checkpoint inhibitors

BackgroundThe risk of immune-related colitis (IRC) and efficacy of immune checkpoint inhibitors (ICIs) in patients with gastrointestinal cancers and preexisting ulcerative colitis (UC) has not been well described.Patients and methodsWe divided the patients with gastrointestinal cancers and preexisti...

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Bibliographic Details
Main Authors: Shuo Xu, Lu Chen, Kaixuan Liu, Hui Tao, Zhengzheng Ji, Jiamin Wu, Yuanyi Zhao, Qiankun Zhou, Liuying Li, Hanlong Zhu, Yunzhe Wang, Fangyu Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint inhibitors
ulcerative colitis
immune-related colitis
gastrointestinal cancers
survival outcomes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1627680/full
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