Comparative efficacy of fascia iliaca compartment block using liposomal bupivacaine versus ropivacaine for preoperative analgesia in elderly patients with intertrochanteric femur fracture: a randomised controlled trial protocol
Introduction Intertrochanteric femur fractures are common in the elderly, with effective pain management being crucial. Fascia iliaca compartment block (FICB) is a well-established method for preoperative analgesia in these patients, but whether liposomal bupivacaine is more effective for this appli...
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BMJ Publishing Group
2025-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/7/e093756.full |
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| author | Yu Zhang Lei Liu Chong Zhang Jing Dong Zhijun Qin Ji Feng Wencan Wang Chenzhu Yin |
| author_facet | Yu Zhang Lei Liu Chong Zhang Jing Dong Zhijun Qin Ji Feng Wencan Wang Chenzhu Yin |
| author_sort | Yu Zhang |
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| description | Introduction Intertrochanteric femur fractures are common in the elderly, with effective pain management being crucial. Fascia iliaca compartment block (FICB) is a well-established method for preoperative analgesia in these patients, but whether liposomal bupivacaine is more effective for this application remains uncertain. This trial aims to evaluate whether liposomal bupivacaine provides superior preoperative analgesia compared to ropivacaine in elderly patients with intertrochanteric femur fracture.Methods This randomised controlled trial will include 84 elderly patients with intertrochanteric femur fracture. Participants will be randomised to receive either liposomal bupivacaine (n=42) or ropivacaine (n=42) via FICB. The outcomes assessed will include pain intensity, anxiety, sleep quality, additional analgesic requirements and rebound pain from FICB administration until preprocedure. Additionally, the study will evaluate in-hospital complications, as well as clinical outcomes at 30 days postsurgery.Ethics and dissemination Approved by the Ethics Committee of Sichuan Province Orthopaedic Hospital (Approval No. KY2023-045-01), the study will be published in a peer-reviewed journal. Results will offer evidence-based insights into optimal preoperative analgesia for this patient population.Trial registration number ChiCTR2400082747. |
| format | Article |
| id | doaj-art-073f89dd7d8b4736bb374388561d0484 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-073f89dd7d8b4736bb374388561d04842025-08-20T03:50:53ZengBMJ Publishing GroupBMJ Open2044-60552025-07-0115710.1136/bmjopen-2024-093756Comparative efficacy of fascia iliaca compartment block using liposomal bupivacaine versus ropivacaine for preoperative analgesia in elderly patients with intertrochanteric femur fracture: a randomised controlled trial protocolYu Zhang0Lei Liu1Chong Zhang2Jing Dong3Zhijun Qin4Ji Feng5Wencan Wang6Chenzhu Yin7Department of Anesthesiology, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, ChinaHospital Infection Management Department, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, ChinaDepartment of Anesthesiology, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, ChinaDepartment of Anesthesiology, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, ChinaDepartment of Anesthesiology, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, ChinaDepartment of Anesthesiology, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, ChinaDepartment of Anesthesiology, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, ChinaDepartment of Anesthesiology, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, ChinaIntroduction Intertrochanteric femur fractures are common in the elderly, with effective pain management being crucial. Fascia iliaca compartment block (FICB) is a well-established method for preoperative analgesia in these patients, but whether liposomal bupivacaine is more effective for this application remains uncertain. This trial aims to evaluate whether liposomal bupivacaine provides superior preoperative analgesia compared to ropivacaine in elderly patients with intertrochanteric femur fracture.Methods This randomised controlled trial will include 84 elderly patients with intertrochanteric femur fracture. Participants will be randomised to receive either liposomal bupivacaine (n=42) or ropivacaine (n=42) via FICB. The outcomes assessed will include pain intensity, anxiety, sleep quality, additional analgesic requirements and rebound pain from FICB administration until preprocedure. Additionally, the study will evaluate in-hospital complications, as well as clinical outcomes at 30 days postsurgery.Ethics and dissemination Approved by the Ethics Committee of Sichuan Province Orthopaedic Hospital (Approval No. KY2023-045-01), the study will be published in a peer-reviewed journal. Results will offer evidence-based insights into optimal preoperative analgesia for this patient population.Trial registration number ChiCTR2400082747.https://bmjopen.bmj.com/content/15/7/e093756.full |
| spellingShingle | Yu Zhang Lei Liu Chong Zhang Jing Dong Zhijun Qin Ji Feng Wencan Wang Chenzhu Yin Comparative efficacy of fascia iliaca compartment block using liposomal bupivacaine versus ropivacaine for preoperative analgesia in elderly patients with intertrochanteric femur fracture: a randomised controlled trial protocol BMJ Open |
| title | Comparative efficacy of fascia iliaca compartment block using liposomal bupivacaine versus ropivacaine for preoperative analgesia in elderly patients with intertrochanteric femur fracture: a randomised controlled trial protocol |
| title_full | Comparative efficacy of fascia iliaca compartment block using liposomal bupivacaine versus ropivacaine for preoperative analgesia in elderly patients with intertrochanteric femur fracture: a randomised controlled trial protocol |
| title_fullStr | Comparative efficacy of fascia iliaca compartment block using liposomal bupivacaine versus ropivacaine for preoperative analgesia in elderly patients with intertrochanteric femur fracture: a randomised controlled trial protocol |
| title_full_unstemmed | Comparative efficacy of fascia iliaca compartment block using liposomal bupivacaine versus ropivacaine for preoperative analgesia in elderly patients with intertrochanteric femur fracture: a randomised controlled trial protocol |
| title_short | Comparative efficacy of fascia iliaca compartment block using liposomal bupivacaine versus ropivacaine for preoperative analgesia in elderly patients with intertrochanteric femur fracture: a randomised controlled trial protocol |
| title_sort | comparative efficacy of fascia iliaca compartment block using liposomal bupivacaine versus ropivacaine for preoperative analgesia in elderly patients with intertrochanteric femur fracture a randomised controlled trial protocol |
| url | https://bmjopen.bmj.com/content/15/7/e093756.full |
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