Terahertz Photonic Crystal Fiber Sensor for Cancer Cell Detection: Performance Analysis and Discrimination
ABSTRACT Background Cancer cells exhibit significant heterogeneity, making their detection a challenging task. Methods In this study, a unique Photonic Crystal Fiber (PCF) sensor with a circular core design and curved trapezoidal cladding is presented. It is especially designed to detect cancer cell...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-07-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.71024 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849247217244700672 |
|---|---|
| author | Kayab Khandakar Md. Omar Faruk A. H. M. Iftekharul Ferdous Md. Naimur Rahman Naim |
| author_facet | Kayab Khandakar Md. Omar Faruk A. H. M. Iftekharul Ferdous Md. Naimur Rahman Naim |
| author_sort | Kayab Khandakar |
| collection | DOAJ |
| description | ABSTRACT Background Cancer cells exhibit significant heterogeneity, making their detection a challenging task. Methods In this study, a unique Photonic Crystal Fiber (PCF) sensor with a circular core design and curved trapezoidal cladding is presented. It is especially designed to detect cancer cells efficiently. Results The proposed sensor demonstrates exceptional performance, achieving a maximum relative sensitivity (RS) of 99.71% for breast cancer type II cells, along with similarly high sensitivities for cervical, adrenal gland, skin, blood, and breast cancer type I cells. Key performance parameters highlight its accuracy in detecting cancer cells via minute changes in refractive index (RI), including ultra‐low confinement loss (CL) of up to 6.69 × 10−13 dB/cm and effective material loss (EML) as low as 0.00161 cm−1. Conclusions The sensor's high accuracy, rapid response time, and ability to selectively target tumor cells make it a breakthrough in early cancer detection. Moreover, its compact size and potential for easy fabrication enhance its applicability in emergency settings. This cutting‐edge approach represents a major advancement in medical technology, paving the way for more efficient and targeted cancer diagnostics. |
| format | Article |
| id | doaj-art-073ce02a3f324334a79d7164983c19f9 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-073ce02a3f324334a79d7164983c19f92025-08-20T03:58:18ZengWileyCancer Medicine2045-76342025-07-011413n/an/a10.1002/cam4.71024Terahertz Photonic Crystal Fiber Sensor for Cancer Cell Detection: Performance Analysis and DiscriminationKayab Khandakar0Md. Omar Faruk1A. H. M. Iftekharul Ferdous2Md. Naimur Rahman Naim3Electrical and Electronic Engineering Department Pabna University of Science and Technology Pabna BangladeshElectrical and Electronic Engineering Department Pabna University of Science and Technology Pabna BangladeshElectrical and Electronic Engineering Department Pabna University of Science and Technology Pabna BangladeshElectrical and Electronic Engineering Department Pabna University of Science and Technology Pabna BangladeshABSTRACT Background Cancer cells exhibit significant heterogeneity, making their detection a challenging task. Methods In this study, a unique Photonic Crystal Fiber (PCF) sensor with a circular core design and curved trapezoidal cladding is presented. It is especially designed to detect cancer cells efficiently. Results The proposed sensor demonstrates exceptional performance, achieving a maximum relative sensitivity (RS) of 99.71% for breast cancer type II cells, along with similarly high sensitivities for cervical, adrenal gland, skin, blood, and breast cancer type I cells. Key performance parameters highlight its accuracy in detecting cancer cells via minute changes in refractive index (RI), including ultra‐low confinement loss (CL) of up to 6.69 × 10−13 dB/cm and effective material loss (EML) as low as 0.00161 cm−1. Conclusions The sensor's high accuracy, rapid response time, and ability to selectively target tumor cells make it a breakthrough in early cancer detection. Moreover, its compact size and potential for easy fabrication enhance its applicability in emergency settings. This cutting‐edge approach represents a major advancement in medical technology, paving the way for more efficient and targeted cancer diagnostics.https://doi.org/10.1002/cam4.71024confinement loss (CL)effective area (EA)effective material loss (EML)numerical aperture (NA)refractive index (RI)relative sensitivity (RS) |
| spellingShingle | Kayab Khandakar Md. Omar Faruk A. H. M. Iftekharul Ferdous Md. Naimur Rahman Naim Terahertz Photonic Crystal Fiber Sensor for Cancer Cell Detection: Performance Analysis and Discrimination Cancer Medicine confinement loss (CL) effective area (EA) effective material loss (EML) numerical aperture (NA) refractive index (RI) relative sensitivity (RS) |
| title | Terahertz Photonic Crystal Fiber Sensor for Cancer Cell Detection: Performance Analysis and Discrimination |
| title_full | Terahertz Photonic Crystal Fiber Sensor for Cancer Cell Detection: Performance Analysis and Discrimination |
| title_fullStr | Terahertz Photonic Crystal Fiber Sensor for Cancer Cell Detection: Performance Analysis and Discrimination |
| title_full_unstemmed | Terahertz Photonic Crystal Fiber Sensor for Cancer Cell Detection: Performance Analysis and Discrimination |
| title_short | Terahertz Photonic Crystal Fiber Sensor for Cancer Cell Detection: Performance Analysis and Discrimination |
| title_sort | terahertz photonic crystal fiber sensor for cancer cell detection performance analysis and discrimination |
| topic | confinement loss (CL) effective area (EA) effective material loss (EML) numerical aperture (NA) refractive index (RI) relative sensitivity (RS) |
| url | https://doi.org/10.1002/cam4.71024 |
| work_keys_str_mv | AT kayabkhandakar terahertzphotoniccrystalfibersensorforcancercelldetectionperformanceanalysisanddiscrimination AT mdomarfaruk terahertzphotoniccrystalfibersensorforcancercelldetectionperformanceanalysisanddiscrimination AT ahmiftekharulferdous terahertzphotoniccrystalfibersensorforcancercelldetectionperformanceanalysisanddiscrimination AT mdnaimurrahmannaim terahertzphotoniccrystalfibersensorforcancercelldetectionperformanceanalysisanddiscrimination |