The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort Study
Dong Li,1,* Youwen Fan,1,* Benyi He,2,3 Yajun Tang,1 Gang Deng,1 Rongping Guo,2,3 Min Deng,1 Di Tang1 1Department of General Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, People’s Republic of China; 2Department of Liver Surgery, Sun Yat-sen Unive...
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Dove Medical Press
2025-07-01
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| Series: | Journal of Inflammation Research |
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| author | Li D Fan Y He B Tang Y Deng G Guo R Deng M Tang D |
| author_facet | Li D Fan Y He B Tang Y Deng G Guo R Deng M Tang D |
| author_sort | Li D |
| collection | DOAJ |
| description | Dong Li,1,&ast; Youwen Fan,1,&ast; Benyi He,2,3 Yajun Tang,1 Gang Deng,1 Rongping Guo,2,3 Min Deng,1 Di Tang1 1Department of General Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, People’s Republic of China; 2Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China; 3State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Di Tang, Department of General Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, 628 Zhenyuan Road, Shenzhen, People’s Republic of China, Email tangdi@mail.sysu.edu.cn Min Deng, Department of General Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, 628 Zhenyuan Road, Shenzhen, People’s Republic of China, Email dengmin@sysush.comBackground: Clinical tools for predicting prognosis are limited for patients with hepatocellular carcinoma (HCC) undergoing hepatic arterial infusion chemotherapy (HAIC)-based hepatectomy. This study evaluated the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) in patients with HCC who received HAIC-based hepatectomy.Methods: This dual-center retrospective study included 390 patients who received HAIC-based conversion resection to investigate the relationship of NLR and LMR with survival outcomes, adverse events, and risk factors.Results: A total of 390 patients with HCC who received HAIC-based conversion liver resection were included. Patients with NLR ≥ 5 exhibited a significantly shorter overall survival (OS) and recurrence-free survival (RFS) compared to those with NLR < 5 (P = 0.0181 and P = 0.0164, respectively). Patients with LMR ≥ 3 exhibited favorable OS and RFS rates compared to those with LMR < 3 (P = 0.0195 and P = 0.0225, respectively). Similar results were observed in patients who achieved an objective response. NLR ≥ 5 and LMR < 3 were significantly associated with decreased OS and RFS compared to NLR < 5 and LMR ≥ 3 (P = 0.0131, P = 0.0104, P = 0.0055, and P = 0.0329, respectively).Conclusion: NLR and LMR have an effective predictive capability in prognosis for patients with HCC who received HAIC-based conversion surgery. These findings may help surgeons and patients make decisions regarding HAIC-based conversion hepatectomy.Plain Language Summary: Patients with NLR ≥ 5 and LMR < 3 exhibited a significantly shorter OS and RFS than those with NLR < 5 and LMR ≥ 3. NLR≥ 5 and LMR< 3 were significantly associated with decreased OS and RFS compared to NLR < 5 and LMR ≥ 3 for patients who achieved an objective response. Our findings may be useful in guiding surgeons and patients in decision-making regarding HAIC-based conversion hepatectomy.Keywords: hepatic arterial infusion chemotherapy, conversion, hepatocellular carcinoma, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio |
| format | Article |
| id | doaj-art-073c09cdc0c44f9187f2a5b4b66074dd |
| institution | Kabale University |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj-art-073c09cdc0c44f9187f2a5b4b66074dd2025-08-20T03:31:16ZengDove Medical PressJournal of Inflammation Research1178-70312025-07-01Volume 18Issue 186758688104417The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort StudyLi D0Fan Y1He B2Tang Y3Deng G4Guo R5Deng M6Tang D7Department of General SurgeryDepartment of General SurgeryDepartment of Liver Surgery, Sun Yat-sen University Cancer CenterDepartment of General SurgeryDepartment of General SurgeryDepartment of Hepatobiliary Oncology, Department of Liver SurgeryGeneral SurgeryGeneral SurgeryDong Li,1,&ast; Youwen Fan,1,&ast; Benyi He,2,3 Yajun Tang,1 Gang Deng,1 Rongping Guo,2,3 Min Deng,1 Di Tang1 1Department of General Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, People’s Republic of China; 2Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China; 3State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Di Tang, Department of General Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, 628 Zhenyuan Road, Shenzhen, People’s Republic of China, Email tangdi@mail.sysu.edu.cn Min Deng, Department of General Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, 628 Zhenyuan Road, Shenzhen, People’s Republic of China, Email dengmin@sysush.comBackground: Clinical tools for predicting prognosis are limited for patients with hepatocellular carcinoma (HCC) undergoing hepatic arterial infusion chemotherapy (HAIC)-based hepatectomy. This study evaluated the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) in patients with HCC who received HAIC-based hepatectomy.Methods: This dual-center retrospective study included 390 patients who received HAIC-based conversion resection to investigate the relationship of NLR and LMR with survival outcomes, adverse events, and risk factors.Results: A total of 390 patients with HCC who received HAIC-based conversion liver resection were included. Patients with NLR ≥ 5 exhibited a significantly shorter overall survival (OS) and recurrence-free survival (RFS) compared to those with NLR < 5 (P = 0.0181 and P = 0.0164, respectively). Patients with LMR ≥ 3 exhibited favorable OS and RFS rates compared to those with LMR < 3 (P = 0.0195 and P = 0.0225, respectively). Similar results were observed in patients who achieved an objective response. NLR ≥ 5 and LMR < 3 were significantly associated with decreased OS and RFS compared to NLR < 5 and LMR ≥ 3 (P = 0.0131, P = 0.0104, P = 0.0055, and P = 0.0329, respectively).Conclusion: NLR and LMR have an effective predictive capability in prognosis for patients with HCC who received HAIC-based conversion surgery. These findings may help surgeons and patients make decisions regarding HAIC-based conversion hepatectomy.Plain Language Summary: Patients with NLR ≥ 5 and LMR < 3 exhibited a significantly shorter OS and RFS than those with NLR < 5 and LMR ≥ 3. NLR≥ 5 and LMR< 3 were significantly associated with decreased OS and RFS compared to NLR < 5 and LMR ≥ 3 for patients who achieved an objective response. Our findings may be useful in guiding surgeons and patients in decision-making regarding HAIC-based conversion hepatectomy.Keywords: hepatic arterial infusion chemotherapy, conversion, hepatocellular carcinoma, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratiohttps://www.dovepress.com/the-prognostic-value-of-neutrophil-to-lymphocyte-ratio-and-lymphocyte--peer-reviewed-fulltext-article-JIRHepatic arterial infusion chemotherapyConversionHepatocellular carcinomaNeutrophil-to-lymphocyte ratioLymphocyte-to-monocyte ratio |
| spellingShingle | Li D Fan Y He B Tang Y Deng G Guo R Deng M Tang D The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort Study Journal of Inflammation Research Hepatic arterial infusion chemotherapy Conversion Hepatocellular carcinoma Neutrophil-to-lymphocyte ratio Lymphocyte-to-monocyte ratio |
| title | The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort Study |
| title_full | The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort Study |
| title_fullStr | The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort Study |
| title_full_unstemmed | The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort Study |
| title_short | The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort Study |
| title_sort | prognostic value of neutrophil to lymphocyte ratio and lymphocyte to monocyte ratio in patients with hepatocellular carcinoma receiving haic based conversion hepatectomy a dual center retrospective cohort study |
| topic | Hepatic arterial infusion chemotherapy Conversion Hepatocellular carcinoma Neutrophil-to-lymphocyte ratio Lymphocyte-to-monocyte ratio |
| url | https://www.dovepress.com/the-prognostic-value-of-neutrophil-to-lymphocyte-ratio-and-lymphocyte--peer-reviewed-fulltext-article-JIR |
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