A randomized, controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopy
Abstract Background The quality of colonoscopy is significantly influenced by the effectiveness of bowel preparation. In this study, we aimed to evaluate the efficacy, safety, and tolerability of bowel cleansing between a new oral sulfate solution (OSS) and standard polyethylene glycol electrolyte p...
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BMC
2025-04-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03885-0 |
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| author | Dong-Ling Xie Jin-Hui Fan Chan-Juan Fan Ying-Hui Gao Jian-Ping Cheng |
| author_facet | Dong-Ling Xie Jin-Hui Fan Chan-Juan Fan Ying-Hui Gao Jian-Ping Cheng |
| author_sort | Dong-Ling Xie |
| collection | DOAJ |
| description | Abstract Background The quality of colonoscopy is significantly influenced by the effectiveness of bowel preparation. In this study, we aimed to evaluate the efficacy, safety, and tolerability of bowel cleansing between a new oral sulfate solution (OSS) and standard polyethylene glycol electrolyte powder (PEG). Methods This single center, randomized, superiority study recruited 679 outpatients who were assigned to either the new OSS group (Group A) or standard PEG group (Group B). The quality of bowel cleansing was evaluated using the Boston Bowel Preparation Scale (BBPS) and compared between the two groups. Furthermore, data pertaining to the duration of bowel preparation, patient tolerability, and the occurrence of adverse events were also analyzed. Results According to BBPS scores, group A demonstrated significantly higher bowel preparation cleanliness than group B. Additionally, group A achieved superior bowel cleansing, as evidenced by a greater proportion of patients with BBPS scores ≥ 8 compared to group B (75.3% vs. 55.2%, P < 0.05). No severe adverse events were reported during examinations in either group. Conclusions The magnesium sulfate, sodium sulfate, and potassium sulfate concentrated oral solution is a novel, safe, and effective bowel preparation for colonoscopy. Trial registration This study was registered in the Chinese Clinical Trial Registry on 20/02/2024 (clinical trial registration number: ChiCTR2400081004). |
| format | Article |
| id | doaj-art-07337c85177e4330b13d3cecaebd6769 |
| institution | DOAJ |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-07337c85177e4330b13d3cecaebd67692025-08-20T03:13:58ZengBMCBMC Gastroenterology1471-230X2025-04-012511910.1186/s12876-025-03885-0A randomized, controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopyDong-Ling Xie0Jin-Hui Fan1Chan-Juan Fan2Ying-Hui Gao3Jian-Ping Cheng4Department of Gastroenterology and Oncology, Civil Aviation General HospitalCivil Aviation Medicine Center, Civil Aviation Administration of ChinaDepartment of Gastroenterology and Oncology, Civil Aviation General HospitalDepartment of Gastroenterology and Oncology, Civil Aviation General HospitalDepartment of Gastroenterology and Oncology, Civil Aviation General HospitalAbstract Background The quality of colonoscopy is significantly influenced by the effectiveness of bowel preparation. In this study, we aimed to evaluate the efficacy, safety, and tolerability of bowel cleansing between a new oral sulfate solution (OSS) and standard polyethylene glycol electrolyte powder (PEG). Methods This single center, randomized, superiority study recruited 679 outpatients who were assigned to either the new OSS group (Group A) or standard PEG group (Group B). The quality of bowel cleansing was evaluated using the Boston Bowel Preparation Scale (BBPS) and compared between the two groups. Furthermore, data pertaining to the duration of bowel preparation, patient tolerability, and the occurrence of adverse events were also analyzed. Results According to BBPS scores, group A demonstrated significantly higher bowel preparation cleanliness than group B. Additionally, group A achieved superior bowel cleansing, as evidenced by a greater proportion of patients with BBPS scores ≥ 8 compared to group B (75.3% vs. 55.2%, P < 0.05). No severe adverse events were reported during examinations in either group. Conclusions The magnesium sulfate, sodium sulfate, and potassium sulfate concentrated oral solution is a novel, safe, and effective bowel preparation for colonoscopy. Trial registration This study was registered in the Chinese Clinical Trial Registry on 20/02/2024 (clinical trial registration number: ChiCTR2400081004).https://doi.org/10.1186/s12876-025-03885-0Bowel PreparationColonoscopyOral sulfate solutionPolyethylene glycolSide effects |
| spellingShingle | Dong-Ling Xie Jin-Hui Fan Chan-Juan Fan Ying-Hui Gao Jian-Ping Cheng A randomized, controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopy BMC Gastroenterology Bowel Preparation Colonoscopy Oral sulfate solution Polyethylene glycol Side effects |
| title | A randomized, controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopy |
| title_full | A randomized, controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopy |
| title_fullStr | A randomized, controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopy |
| title_full_unstemmed | A randomized, controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopy |
| title_short | A randomized, controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopy |
| title_sort | randomized controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopy |
| topic | Bowel Preparation Colonoscopy Oral sulfate solution Polyethylene glycol Side effects |
| url | https://doi.org/10.1186/s12876-025-03885-0 |
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