Neuromotor functions across the lifespan: percentiles from 6 to 80 years
AimTo investigate the dynamics of neuromotor functions from 6 to 80 years with the Zurich Neuromotor Assessment (ZNA) and to provide reference curves for clinical and research use.Materials and methodsNeuromotor data on 1620 individuals (828 females) measured with the ZNA and ZNA-2 between 1983 and...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1543408/full |
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| Summary: | AimTo investigate the dynamics of neuromotor functions from 6 to 80 years with the Zurich Neuromotor Assessment (ZNA) and to provide reference curves for clinical and research use.Materials and methodsNeuromotor data on 1620 individuals (828 females) measured with the ZNA and ZNA-2 between 1983 and 2023 were extracted from 11 studies, all performed at the same center in the region of Zurich, Switzerland. Performance on 14 motor tasks was modeled as a function of age and sex while controlling for differences in testing procedures that occurred over the period spanned by the studies. The age of peak performance was identified for each task. Motor performance was converted into standard deviation scores (SDSs) at the task level and combined into the five motor components of the ZNA-2: fine motor, pure motor, balance, gross motor, and contralateral associated movements. The effect of body mass index (BMI) on motor component SDSs was also investigated.ResultsThe data showed a rapid increase in motor functions during the first years, particularly before age 10 years, followed by a leveling in performance between the ages of 20 and 40 years. Afterward, a decrease in motor functions was observed in most tasks. However, the age of peak performance and the rate of decline varied greatly between the tasks: motor functions in tasks requiring muscle force deteriorated faster than those involving isolated movements, which showed only mild declines at older ages. Males reached peak performance on average 1 year later than females. High BMI (SDS > 1) was associated with lower balance and poorer gross motor functions.DiscussionNeuromotor functions undergo dynamic changes throughout the lifespan from early childhood to older adulthood, with peak performances and declines depending on type of motor task and sex. High BMI negatively impacts balance and gross motor functions but not other neuromotor domains. Our findings may inform clinical practice and interventions aimed at optimizing motor functions across the lifespan. |
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| ISSN: | 1663-4365 |