Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk + ganciclovir gene therapy for prostate cancer

Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk + ganciclovir gene therapy for prostate cancer

Objective: Cytopathic effects and local immune response were analyzed histologically in prostatic cancer (PCa) with in situ herpes simplex virus-thymidine kinase (HSV-tk)/ganciclovir (GCV) gene therapy (GT). Methods: Four high-risk PCa patients who received HSV-tk/GCV GT were investigated. After two...

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Bibliographic Details
Main Authors: Nobuyuki Yanagisawa, Takefumi Satoh, Ken-ichi Tabata, Hideyasu Tsumura, Yasutomo Nasu, Masami Watanabe, Timothy C. Thompson, Isao Okayasu, Yoshiki Murakumo, Shiro Baba, Masatsugu Iwamura
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Asian Journal of Urology
Subjects:
Suicide gene therapy
Prostate carcinoma
HSV-tk
Ganciclovir
Immunohistochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2214388220300436
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