Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism
Purpose This study aimed to explore the value of preoperative total parathyroid volume (TPV) as a marker for predict recurrence of renal secondary hyperparathyroidism (SHPT).Methods We identified 28 patients with recurrence and 128 without recurrence who underwent total parathyroidectomy with autotr...
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Taylor & Francis Group
2024-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2428435 |
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| author | Zhongkui Wang Fuquan Zhang Chengpei Zhu Chunyue Wu Xiangchao Meng Xudong Wang |
| author_facet | Zhongkui Wang Fuquan Zhang Chengpei Zhu Chunyue Wu Xiangchao Meng Xudong Wang |
| author_sort | Zhongkui Wang |
| collection | DOAJ |
| description | Purpose This study aimed to explore the value of preoperative total parathyroid volume (TPV) as a marker for predict recurrence of renal secondary hyperparathyroidism (SHPT).Methods We identified 28 patients with recurrence and 128 without recurrence who underwent total parathyroidectomy with autotransplantation (tPTX + AT) at our institution between 2015 and 2022. The TPV and postoperative recurrence information of the patients were recorded. Within the intergroup comparison, data obtained from the recurrence and non-recurrence groups were evaluated using the t-test. Univariate and multivariate analyses were performed according to the regression model to determine factors that were significant in predicting postoperative recurrence. The cutoff value of TPV was determined using a receiver operating characteristic (ROC) curve.Results The mean TPV of recurrence and no-recurrence groups were 2.99 ± 1.52 cm3 and 1.73 ± 1.19 cm3, respectively (p = 0.007). In univariate analysis, female sex, total parathyroid volume > 1.99 cm3, serum PTH > 928.37 pg/mL and p > 1.59 mmol/L were independent factors for SHPT recurrence. In multivariable analysis, TPV > 1.99 cm3, serum parathyroid hormone (PTH) > 928.37 pg/mL and p > 1.59 mmol/L were independent factors for SHPT recurrence. The ability of TPV to distinguish between recurrence and non-recurrence was evaluated using the ROC curve. The cutoff value of TPV was estimated as 2.65 cm3. With this value, sensitivity was found as 60.70%, specificity was 89.80%, and AUC was 0.80 (p < 0.001, confidence interval =0.719–0.882).Conclusion According to the data in this study, it can be said that TPV can be used to distinguish recurrence from no-recurrence. Most importantly, TPV can be used to identify SHPT recurrence. |
| format | Article |
| id | doaj-art-0722ad50fb484e1b9df719ff5c2cf361 |
| institution | OA Journals |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | Annals of Medicine |
| spelling | doaj-art-0722ad50fb484e1b9df719ff5c2cf3612025-08-20T02:14:11ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602024-12-0156110.1080/07853890.2024.2428435Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidismZhongkui Wang0Fuquan Zhang1Chengpei Zhu2Chunyue Wu3Xiangchao Meng4Xudong Wang5Department of Maxillofacial and Otorhinolaryngology Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Basic and Translational Medicine on Head& Neck Cancer, Tianjin, Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, National Clinical Research Center of Cancer, Tianjin, ChinaDepartment of General Surgery, Tianjin Third Central Hospital, Tianjin, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of General Surgery, Tianjin Third Central Hospital, Tianjin, ChinaDepartment of General Surgery, Tianjin Third Central Hospital, Tianjin, ChinaDepartment of Maxillofacial and Otorhinolaryngology Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Basic and Translational Medicine on Head& Neck Cancer, Tianjin, Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, National Clinical Research Center of Cancer, Tianjin, ChinaPurpose This study aimed to explore the value of preoperative total parathyroid volume (TPV) as a marker for predict recurrence of renal secondary hyperparathyroidism (SHPT).Methods We identified 28 patients with recurrence and 128 without recurrence who underwent total parathyroidectomy with autotransplantation (tPTX + AT) at our institution between 2015 and 2022. The TPV and postoperative recurrence information of the patients were recorded. Within the intergroup comparison, data obtained from the recurrence and non-recurrence groups were evaluated using the t-test. Univariate and multivariate analyses were performed according to the regression model to determine factors that were significant in predicting postoperative recurrence. The cutoff value of TPV was determined using a receiver operating characteristic (ROC) curve.Results The mean TPV of recurrence and no-recurrence groups were 2.99 ± 1.52 cm3 and 1.73 ± 1.19 cm3, respectively (p = 0.007). In univariate analysis, female sex, total parathyroid volume > 1.99 cm3, serum PTH > 928.37 pg/mL and p > 1.59 mmol/L were independent factors for SHPT recurrence. In multivariable analysis, TPV > 1.99 cm3, serum parathyroid hormone (PTH) > 928.37 pg/mL and p > 1.59 mmol/L were independent factors for SHPT recurrence. The ability of TPV to distinguish between recurrence and non-recurrence was evaluated using the ROC curve. The cutoff value of TPV was estimated as 2.65 cm3. With this value, sensitivity was found as 60.70%, specificity was 89.80%, and AUC was 0.80 (p < 0.001, confidence interval =0.719–0.882).Conclusion According to the data in this study, it can be said that TPV can be used to distinguish recurrence from no-recurrence. Most importantly, TPV can be used to identify SHPT recurrence.https://www.tandfonline.com/doi/10.1080/07853890.2024.2428435Secondary hyperparathyroidismtotal parathyroid volumerecurrence |
| spellingShingle | Zhongkui Wang Fuquan Zhang Chengpei Zhu Chunyue Wu Xiangchao Meng Xudong Wang Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism Annals of Medicine Secondary hyperparathyroidism total parathyroid volume recurrence |
| title | Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism |
| title_full | Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism |
| title_fullStr | Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism |
| title_full_unstemmed | Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism |
| title_short | Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism |
| title_sort | preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism |
| topic | Secondary hyperparathyroidism total parathyroid volume recurrence |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2428435 |
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