Interactions between leukemia and feeders in co-cultivation under hypoxia

Abstract Background Leukemia is driven by complex interactions within the inherently hypoxic bone marrow microenvironment, impacting both disease progression and therapeutic resistance. Co-cultivation of leukemic cells with feeder cells has emerged as a valuable tool to mimic the bone marrow niche....

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Bibliographic Details
Main Authors: Miriama Sikorová, Pavel Klener, Pavla Tonarová, Marie Hubálek Kalbáčová
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
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Online Access:https://doi.org/10.1186/s12885-025-13988-2
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