Genetics of Childhood Obesity
Obesity is a major health problem and an immense economic burden on the health care systems both in the United States and the rest of the world. The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genet...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/845148 |
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| _version_ | 1832567351037394944 |
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| author | Jianhua Zhao Struan F. A. Grant |
| author_facet | Jianhua Zhao Struan F. A. Grant |
| author_sort | Jianhua Zhao |
| collection | DOAJ |
| description | Obesity is a major health problem and an immense economic burden on the health care systems both in the United States and the rest of the world. The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. Genome-wide association studies (GWAS) have revealed strongly associated genomic variants associated with most common disorders; indeed there is general consensus on these findings from generally positive replication outcomes by independent groups. To date, there have been only a few GWAS-related reports for childhood obesity specifically, with studies primarily uncovering loci in the adult setting instead. It is clear that a number of loci previously reported from GWAS analyses of adult BMI and/or obesity also play a role in childhood obesity. |
| format | Article |
| id | doaj-art-071d85b74b6e40b59b668a457f859d7c |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-071d85b74b6e40b59b668a457f859d7c2025-02-03T01:01:38ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/845148845148Genetics of Childhood ObesityJianhua Zhao0Struan F. A. Grant1Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USADivision of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USAObesity is a major health problem and an immense economic burden on the health care systems both in the United States and the rest of the world. The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. Genome-wide association studies (GWAS) have revealed strongly associated genomic variants associated with most common disorders; indeed there is general consensus on these findings from generally positive replication outcomes by independent groups. To date, there have been only a few GWAS-related reports for childhood obesity specifically, with studies primarily uncovering loci in the adult setting instead. It is clear that a number of loci previously reported from GWAS analyses of adult BMI and/or obesity also play a role in childhood obesity.http://dx.doi.org/10.1155/2011/845148 |
| spellingShingle | Jianhua Zhao Struan F. A. Grant Genetics of Childhood Obesity Journal of Obesity |
| title | Genetics of Childhood Obesity |
| title_full | Genetics of Childhood Obesity |
| title_fullStr | Genetics of Childhood Obesity |
| title_full_unstemmed | Genetics of Childhood Obesity |
| title_short | Genetics of Childhood Obesity |
| title_sort | genetics of childhood obesity |
| url | http://dx.doi.org/10.1155/2011/845148 |
| work_keys_str_mv | AT jianhuazhao geneticsofchildhoodobesity AT struanfagrant geneticsofchildhoodobesity |