Preparation, characterization, and application of a valine-malonic acid based-DES as a potent catalyst for the green synthesis of thiazolopyrimidines
Abstract Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (VAL/MAL-DES) was prepared by a mixture of one mole of valine (VAL) and one mole of malonic acid (MAL), and characterized by the eutectic points, FT-IR, 1HNMR, TGA/DTA and densitometer techniques. Then, it was...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-03630-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849687921258397696 |
|---|---|
| author | Nastaran Dehnokhalaji Davood Habibi Arezo Monem Afagh Ranjbaran |
| author_facet | Nastaran Dehnokhalaji Davood Habibi Arezo Monem Afagh Ranjbaran |
| author_sort | Nastaran Dehnokhalaji |
| collection | DOAJ |
| description | Abstract Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (VAL/MAL-DES) was prepared by a mixture of one mole of valine (VAL) and one mole of malonic acid (MAL), and characterized by the eutectic points, FT-IR, 1HNMR, TGA/DTA and densitometer techniques. Then, it was used as a novel and capable catalyst for the green synthesis of thiazolo[3,2-a]pyrimidines via a one-pot four-component condensation reaction of 4-hydroxycoumarin, 2-amino-6-methylbenzothiazole, morpholine, and aldehydes at 80 °C with high yield and short reaction time. |
| format | Article |
| id | doaj-art-0719e671ecff4b0fa251ec40753e799a |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-0719e671ecff4b0fa251ec40753e799a2025-08-20T03:22:12ZengNature PortfolioScientific Reports2045-23222025-05-0115111610.1038/s41598-025-03630-3Preparation, characterization, and application of a valine-malonic acid based-DES as a potent catalyst for the green synthesis of thiazolopyrimidinesNastaran Dehnokhalaji0Davood Habibi1Arezo Monem2Afagh Ranjbaran3Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityAbstract Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (VAL/MAL-DES) was prepared by a mixture of one mole of valine (VAL) and one mole of malonic acid (MAL), and characterized by the eutectic points, FT-IR, 1HNMR, TGA/DTA and densitometer techniques. Then, it was used as a novel and capable catalyst for the green synthesis of thiazolo[3,2-a]pyrimidines via a one-pot four-component condensation reaction of 4-hydroxycoumarin, 2-amino-6-methylbenzothiazole, morpholine, and aldehydes at 80 °C with high yield and short reaction time.https://doi.org/10.1038/s41598-025-03630-3Natural deep eutectic solventValineMalonic acidHomogeneous catalysisMulticomponent reactions |
| spellingShingle | Nastaran Dehnokhalaji Davood Habibi Arezo Monem Afagh Ranjbaran Preparation, characterization, and application of a valine-malonic acid based-DES as a potent catalyst for the green synthesis of thiazolopyrimidines Scientific Reports Natural deep eutectic solvent Valine Malonic acid Homogeneous catalysis Multicomponent reactions |
| title | Preparation, characterization, and application of a valine-malonic acid based-DES as a potent catalyst for the green synthesis of thiazolopyrimidines |
| title_full | Preparation, characterization, and application of a valine-malonic acid based-DES as a potent catalyst for the green synthesis of thiazolopyrimidines |
| title_fullStr | Preparation, characterization, and application of a valine-malonic acid based-DES as a potent catalyst for the green synthesis of thiazolopyrimidines |
| title_full_unstemmed | Preparation, characterization, and application of a valine-malonic acid based-DES as a potent catalyst for the green synthesis of thiazolopyrimidines |
| title_short | Preparation, characterization, and application of a valine-malonic acid based-DES as a potent catalyst for the green synthesis of thiazolopyrimidines |
| title_sort | preparation characterization and application of a valine malonic acid based des as a potent catalyst for the green synthesis of thiazolopyrimidines |
| topic | Natural deep eutectic solvent Valine Malonic acid Homogeneous catalysis Multicomponent reactions |
| url | https://doi.org/10.1038/s41598-025-03630-3 |
| work_keys_str_mv | AT nastarandehnokhalaji preparationcharacterizationandapplicationofavalinemalonicacidbaseddesasapotentcatalystforthegreensynthesisofthiazolopyrimidines AT davoodhabibi preparationcharacterizationandapplicationofavalinemalonicacidbaseddesasapotentcatalystforthegreensynthesisofthiazolopyrimidines AT arezomonem preparationcharacterizationandapplicationofavalinemalonicacidbaseddesasapotentcatalystforthegreensynthesisofthiazolopyrimidines AT afaghranjbaran preparationcharacterizationandapplicationofavalinemalonicacidbaseddesasapotentcatalystforthegreensynthesisofthiazolopyrimidines |