Preparation, characterization, and application of a valine-malonic acid based-DES as a potent catalyst for the green synthesis of thiazolopyrimidines
Abstract Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (VAL/MAL-DES) was prepared by a mixture of one mole of valine (VAL) and one mole of malonic acid (MAL), and characterized by the eutectic points, FT-IR, 1HNMR, TGA/DTA and densitometer techniques. Then, it was...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-03630-3 |
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| Summary: | Abstract Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (VAL/MAL-DES) was prepared by a mixture of one mole of valine (VAL) and one mole of malonic acid (MAL), and characterized by the eutectic points, FT-IR, 1HNMR, TGA/DTA and densitometer techniques. Then, it was used as a novel and capable catalyst for the green synthesis of thiazolo[3,2-a]pyrimidines via a one-pot four-component condensation reaction of 4-hydroxycoumarin, 2-amino-6-methylbenzothiazole, morpholine, and aldehydes at 80 °C with high yield and short reaction time. |
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| ISSN: | 2045-2322 |