IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma

IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma

Summary: The rate-limiting isozyme of de novo guanosine biosynthesis, IMPDH2, was identified as an essential gene in Merkel cell carcinoma (MCC) but the consequences of its functional disruption were unclear. Inhibition of IMPDH2 led to reduced MCC cell viability, independent of functional p53 or Me...

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Bibliographic Details
Main Authors: Julia L. Schnabel, Thomas C. Frost, Adam C. Wang, Varsha Ananthapadmanabhan, Satvik Gurram, Kara M. Soroko, Prafulla C. Gokhale, James A. DeCaprio
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Health sciences
Cell biology
Cancer systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225008284
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