Relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with COVID-19
IntroductionConcurrent alterations in the metabolic profile and thyroid dysfunction, including non-thyroidal illness syndrome (NTIS) has been reported in multisystem inflammatory syndrome in children (MIS-C). Considering the influence of thyroid hormones (TH) on lipid metabolism, we explored the rel...
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1456545/full |
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| author | Valeria Calcaterra Valeria Calcaterra Raffaella De Santis Davide Braghieri Sara Zanelli Gianvincenzo Zuccotti Gianvincenzo Zuccotti |
| author_facet | Valeria Calcaterra Valeria Calcaterra Raffaella De Santis Davide Braghieri Sara Zanelli Gianvincenzo Zuccotti Gianvincenzo Zuccotti |
| author_sort | Valeria Calcaterra |
| collection | DOAJ |
| description | IntroductionConcurrent alterations in the metabolic profile and thyroid dysfunction, including non-thyroidal illness syndrome (NTIS) has been reported in multisystem inflammatory syndrome in children (MIS-C). Considering the influence of thyroid hormones (TH) on lipid metabolism, we explored the relationship between thyroid function and the atherogenic lipid profile in children with MIS-C at admission and during a 12-month follow-up.Patients and methodswe considered children admitted for MIS-C. Total and HDL cholesterol, triglycerides (TG), fasting plasma glucose, fasting plasma insulin as well as free T3 (FT3), free T4 (FT4), and TSH were assessed at diagnosis within 24 h of admission and during follow-up. TG/HDL ratio, no-HDL/HDL ratio and atherogenic index of plasma was also considered as atherogenic risk markers.Resultswe monitored 56 children. On admission, pathological levels of FT3, FT4, TSH, TG, TC, HDL, TG/HDL ratio, no-HDL/HDL ratio, and AIP were detected. Correlation analyses revealed associations between FT3, FT4, and lipid markers and TSH with TG. During monitoring, while complete restoration of TH balance was achieved at 12 months, some patients still exhibited an altered lipid profile, without correlation between thyroid function and lipid markers.Conclusionswe supported a relationship between thyroid function and an atherogenic lipid profile in children with MIS-C. This may result from interactions between adaptive and innate metabolic responses and genetic predisposition. Elucidating the relationship between TH and metabolic pathways during infections could help identify new biomarkers to prevent acute and fatal outcomes, improving patient prognosis and protecting long-term health. |
| format | Article |
| id | doaj-art-070fc68a3d6d415d97e3d9e91bf3ea1e |
| institution | OA Journals |
| issn | 2296-2360 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-070fc68a3d6d415d97e3d9e91bf3ea1e2025-08-20T02:12:14ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-10-011210.3389/fped.2024.14565451456545Relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with COVID-19Valeria Calcaterra0Valeria Calcaterra1Raffaella De Santis2Davide Braghieri3Sara Zanelli4Gianvincenzo Zuccotti5Gianvincenzo Zuccotti6Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, ItalyPediatric Department, “Vittore Buzzi” Children’s Hospital, Milano, ItalyPediatric Department, “Vittore Buzzi” Children’s Hospital, Milano, ItalyPediatric Department, “Vittore Buzzi” Children’s Hospital, Milano, ItalyPediatric Department, “Vittore Buzzi” Children’s Hospital, Milano, ItalyPediatric Department, “Vittore Buzzi” Children’s Hospital, Milano, ItalyDepartment of Biomedical and Clinical Science, University of Milano, Milano, ItalyIntroductionConcurrent alterations in the metabolic profile and thyroid dysfunction, including non-thyroidal illness syndrome (NTIS) has been reported in multisystem inflammatory syndrome in children (MIS-C). Considering the influence of thyroid hormones (TH) on lipid metabolism, we explored the relationship between thyroid function and the atherogenic lipid profile in children with MIS-C at admission and during a 12-month follow-up.Patients and methodswe considered children admitted for MIS-C. Total and HDL cholesterol, triglycerides (TG), fasting plasma glucose, fasting plasma insulin as well as free T3 (FT3), free T4 (FT4), and TSH were assessed at diagnosis within 24 h of admission and during follow-up. TG/HDL ratio, no-HDL/HDL ratio and atherogenic index of plasma was also considered as atherogenic risk markers.Resultswe monitored 56 children. On admission, pathological levels of FT3, FT4, TSH, TG, TC, HDL, TG/HDL ratio, no-HDL/HDL ratio, and AIP were detected. Correlation analyses revealed associations between FT3, FT4, and lipid markers and TSH with TG. During monitoring, while complete restoration of TH balance was achieved at 12 months, some patients still exhibited an altered lipid profile, without correlation between thyroid function and lipid markers.Conclusionswe supported a relationship between thyroid function and an atherogenic lipid profile in children with MIS-C. This may result from interactions between adaptive and innate metabolic responses and genetic predisposition. Elucidating the relationship between TH and metabolic pathways during infections could help identify new biomarkers to prevent acute and fatal outcomes, improving patient prognosis and protecting long-term health.https://www.frontiersin.org/articles/10.3389/fped.2024.1456545/fullthyroidnon-thyroidal illness syndromemultisystem inflammatory syndromechildren thyroid hormoneslipid metabolismlipid atherogenic profile |
| spellingShingle | Valeria Calcaterra Valeria Calcaterra Raffaella De Santis Davide Braghieri Sara Zanelli Gianvincenzo Zuccotti Gianvincenzo Zuccotti Relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with COVID-19 Frontiers in Pediatrics thyroid non-thyroidal illness syndrome multisystem inflammatory syndrome children thyroid hormones lipid metabolism lipid atherogenic profile |
| title | Relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with COVID-19 |
| title_full | Relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with COVID-19 |
| title_fullStr | Relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with COVID-19 |
| title_full_unstemmed | Relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with COVID-19 |
| title_short | Relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with COVID-19 |
| title_sort | relationship between thyroid function and lipid atherogenic profile in pediatric patients with multisystem inflammatory syndrome associated with covid 19 |
| topic | thyroid non-thyroidal illness syndrome multisystem inflammatory syndrome children thyroid hormones lipid metabolism lipid atherogenic profile |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1456545/full |
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