Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine
Toxic epidermal necrolysis is the most severe form of drug-induced skin reaction and includes denudation of >30% of total body surface area. The mechanism of disease is not completely understood, but immunologic mechanisms, cytotoxic reactions, and delayed hypersensitivity seem to be involved. We...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/931528 |
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| _version_ | 1850233831093698560 |
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| author | Carlos Saavedra Paola Cárdenas Héctor Castellanos Kateir Contreras J. R. Castro |
| author_facet | Carlos Saavedra Paola Cárdenas Héctor Castellanos Kateir Contreras J. R. Castro |
| author_sort | Carlos Saavedra |
| collection | DOAJ |
| description | Toxic epidermal necrolysis is the most severe form of drug-induced skin reaction and includes denudation of >30% of total body surface area. The mechanism of disease is not completely understood, but immunologic mechanisms, cytotoxic reactions, and delayed hypersensitivity seem to be involved. We report a case of cephazolin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and N-acetylcysteine with excellent response. |
| format | Article |
| id | doaj-art-0709cd6f49e74545b4fe3ce8f2226448 |
| institution | OA Journals |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-0709cd6f49e74545b4fe3ce8f22264482025-08-20T02:02:50ZengWileyCase Reports in Immunology2090-66092090-66172012-01-01201210.1155/2012/931528931528Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-AcetylcysteineCarlos Saavedra0Paola Cárdenas1Héctor Castellanos2Kateir Contreras3J. R. Castro4Units of Infectology and Dermatology, Department of Internal Medicine, National University of Colombia, 111321 Bogotá, ColombiaUnits of Infectology and Dermatology, Department of Internal Medicine, National University of Colombia, 111321 Bogotá, ColombiaUnits of Infectology and Dermatology, Department of Internal Medicine, National University of Colombia, 111321 Bogotá, ColombiaUnits of Infectology and Dermatology, Department of Internal Medicine, National University of Colombia, 111321 Bogotá, ColombiaUnits of Infectology and Dermatology, Department of Internal Medicine, National University of Colombia, 111321 Bogotá, ColombiaToxic epidermal necrolysis is the most severe form of drug-induced skin reaction and includes denudation of >30% of total body surface area. The mechanism of disease is not completely understood, but immunologic mechanisms, cytotoxic reactions, and delayed hypersensitivity seem to be involved. We report a case of cephazolin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and N-acetylcysteine with excellent response.http://dx.doi.org/10.1155/2012/931528 |
| spellingShingle | Carlos Saavedra Paola Cárdenas Héctor Castellanos Kateir Contreras J. R. Castro Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine Case Reports in Immunology |
| title | Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine |
| title_full | Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine |
| title_fullStr | Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine |
| title_full_unstemmed | Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine |
| title_short | Cephazolin-Induced Toxic Epidermal Necrolysis Treated with Intravenous Immunoglobulin and N-Acetylcysteine |
| title_sort | cephazolin induced toxic epidermal necrolysis treated with intravenous immunoglobulin and n acetylcysteine |
| url | http://dx.doi.org/10.1155/2012/931528 |
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