Human Cystic Echinococcosis: Old Problems and New Perspectives
Cystic echinococcosis (CE) is a widespread chronic endemic helminthic disease caused by infection with metacestodes of the tapeworm Echinococcus granulosus. CE affects humans and has a worldwide prevalence of approximately six million. In this review, we discuss current findings in diagnosis and cli...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2009/474368 |
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| _version_ | 1850233829338382336 |
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| author | Alessandra Siracusano Antonella Teggi Elena Ortona |
| author_facet | Alessandra Siracusano Antonella Teggi Elena Ortona |
| author_sort | Alessandra Siracusano |
| collection | DOAJ |
| description | Cystic echinococcosis (CE) is a widespread chronic endemic helminthic disease caused by infection with metacestodes of the tapeworm Echinococcus granulosus. CE affects humans and has a worldwide prevalence of approximately six million. In this review, we discuss current findings in diagnosis and clinical management of CE and new concepts relating to E. granulosus molecules that directly modulate the host immune responses favouring a strong anti-inflammatory response and perpetuating parasite survival in the host. New insights into the molecular biology of E. granulosus will improve considerably our knowledge of the disease and will provide new potential therapeutic applications to treat or prevent inflammatory immune-mediated disease. |
| format | Article |
| id | doaj-art-07024580dc1b492eb25b68ab17af1e21 |
| institution | OA Journals |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-07024580dc1b492eb25b68ab17af1e212025-08-20T02:02:50ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982009-01-01200910.1155/2009/474368474368Human Cystic Echinococcosis: Old Problems and New PerspectivesAlessandra Siracusano0Antonella Teggi1Elena Ortona2Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, ItalyDipartimento di Malattie Infettive e Tropicali, Ospedale Sant'Andrea, Università di Roma, “Sapienza”, 00189 Roma, ItalyDipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, ItalyCystic echinococcosis (CE) is a widespread chronic endemic helminthic disease caused by infection with metacestodes of the tapeworm Echinococcus granulosus. CE affects humans and has a worldwide prevalence of approximately six million. In this review, we discuss current findings in diagnosis and clinical management of CE and new concepts relating to E. granulosus molecules that directly modulate the host immune responses favouring a strong anti-inflammatory response and perpetuating parasite survival in the host. New insights into the molecular biology of E. granulosus will improve considerably our knowledge of the disease and will provide new potential therapeutic applications to treat or prevent inflammatory immune-mediated disease.http://dx.doi.org/10.1155/2009/474368 |
| spellingShingle | Alessandra Siracusano Antonella Teggi Elena Ortona Human Cystic Echinococcosis: Old Problems and New Perspectives Interdisciplinary Perspectives on Infectious Diseases |
| title | Human Cystic Echinococcosis: Old Problems and New Perspectives |
| title_full | Human Cystic Echinococcosis: Old Problems and New Perspectives |
| title_fullStr | Human Cystic Echinococcosis: Old Problems and New Perspectives |
| title_full_unstemmed | Human Cystic Echinococcosis: Old Problems and New Perspectives |
| title_short | Human Cystic Echinococcosis: Old Problems and New Perspectives |
| title_sort | human cystic echinococcosis old problems and new perspectives |
| url | http://dx.doi.org/10.1155/2009/474368 |
| work_keys_str_mv | AT alessandrasiracusano humancysticechinococcosisoldproblemsandnewperspectives AT antonellateggi humancysticechinococcosisoldproblemsandnewperspectives AT elenaortona humancysticechinococcosisoldproblemsandnewperspectives |