Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social skills and the presence of repetitive and restricted behaviors and interests. The social behavior of the zebrafish (Danio rerio) makes this organism a valuable tool for modeling ASD in order to explor...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2073-4409/14/2/109 |
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| author | Diletta Camussi Maria Marchese Ferdinando Nicoletti Filippo Maria Santorelli Asahi Ogi |
| author_facet | Diletta Camussi Maria Marchese Ferdinando Nicoletti Filippo Maria Santorelli Asahi Ogi |
| author_sort | Diletta Camussi |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social skills and the presence of repetitive and restricted behaviors and interests. The social behavior of the zebrafish (Danio rerio) makes this organism a valuable tool for modeling ASD in order to explore the social impairment typical of this disorder. In addition to transgenic models, exposure of zebrafish embryos to valproic acid (VPA) has been found to produce ASD-like symptoms. This review first sets out to examine the existing literature on adult social behavior in the zebrafish VPA-induced model of autism, and the authors also aim to identify the ideal VPA dosage able to induce a persistent and long-lasting ASD-like phenotype while minimizing the suffering and distress of research animals in compliance with the principles of replacement, refinement, and reduction (3Rs). |
| format | Article |
| id | doaj-art-06fee1545f774673bcb3975b048e8946 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-06fee1545f774673bcb3975b048e89462025-01-24T13:26:42ZengMDPI AGCells2073-44092025-01-0114210910.3390/cells14020109Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic ReviewDiletta Camussi0Maria Marchese1Ferdinando Nicoletti2Filippo Maria Santorelli3Asahi Ogi4IRCCS Stella Maris Foundation, 56128 Pisa, ItalyIRCCS Stella Maris Foundation, 56128 Pisa, ItalyDepartment of Physiology and Pharmacology Vittorio Erspamer, “La Sapienza” University of Rome, 00185 Rome, ItalyIRCCS Stella Maris Foundation, 56128 Pisa, ItalyIRCCS Stella Maris Foundation, 56128 Pisa, ItalyAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social skills and the presence of repetitive and restricted behaviors and interests. The social behavior of the zebrafish (Danio rerio) makes this organism a valuable tool for modeling ASD in order to explore the social impairment typical of this disorder. In addition to transgenic models, exposure of zebrafish embryos to valproic acid (VPA) has been found to produce ASD-like symptoms. This review first sets out to examine the existing literature on adult social behavior in the zebrafish VPA-induced model of autism, and the authors also aim to identify the ideal VPA dosage able to induce a persistent and long-lasting ASD-like phenotype while minimizing the suffering and distress of research animals in compliance with the principles of replacement, refinement, and reduction (3Rs).https://www.mdpi.com/2073-4409/14/2/109adult zebrafishsocial behaviorautism spectrum disordervalproic acidvalproate |
| spellingShingle | Diletta Camussi Maria Marchese Ferdinando Nicoletti Filippo Maria Santorelli Asahi Ogi Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review Cells adult zebrafish social behavior autism spectrum disorder valproic acid valproate |
| title | Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review |
| title_full | Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review |
| title_fullStr | Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review |
| title_full_unstemmed | Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review |
| title_short | Valproate-Induced Model of Autism in Adult Zebrafish: A Systematic Review |
| title_sort | valproate induced model of autism in adult zebrafish a systematic review |
| topic | adult zebrafish social behavior autism spectrum disorder valproic acid valproate |
| url | https://www.mdpi.com/2073-4409/14/2/109 |
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