PGRP-S promotes hepatocellular carcinoma progression via MAPK/ERK pathway by interaction with TTC1
Abstract Abnormal expression of PGRP-S plays an important role in the development and progression of hepatocellular carcinoma (HCC), although the mechanism has remained elusive. In this study, we aimed to investigate the biological function and potential mechanism of PGRP-S in HCC. We found that PGR...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-12160-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849342812490825728 |
|---|---|
| author | Huifang Zhu Shuang Feng Sizhen Lv Di Zhao Xuanhe Chang Shangqian Fan Xia Wang Xinlai Qian |
| author_facet | Huifang Zhu Shuang Feng Sizhen Lv Di Zhao Xuanhe Chang Shangqian Fan Xia Wang Xinlai Qian |
| author_sort | Huifang Zhu |
| collection | DOAJ |
| description | Abstract Abnormal expression of PGRP-S plays an important role in the development and progression of hepatocellular carcinoma (HCC), although the mechanism has remained elusive. In this study, we aimed to investigate the biological function and potential mechanism of PGRP-S in HCC. We found that PGRP-S was upregulated in HCC tissues compared to adjacent tissues. The increased expression of PGRP-S correlated with the differentiation and lymph node metastasis of HCC. PGRP-S obviously promoted HCC cell proliferation, migration and invasion in vitro. In vivo nude mouse models showed that PGRP-S enhanced tumor growth and pulmonary metastasis. Mechanistically, PGRP-S interacted with TTC1 and activated MAPK/ERK pathway, leading to HCC cell proliferation, migration and invasion. Therfore, our conclusion is PGRP-S promotes HCC cell proliferation, migration and invasion by activating MAPK/ERK pathway, which provides a new potential strategy for HCC treatment by targeting PGRP-S-TTC1 axis. |
| format | Article |
| id | doaj-art-06f3343008fa4ccca1609c398d0aa785 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-06f3343008fa4ccca1609c398d0aa7852025-08-20T03:43:15ZengNature PortfolioScientific Reports2045-23222025-08-0115111610.1038/s41598-025-12160-xPGRP-S promotes hepatocellular carcinoma progression via MAPK/ERK pathway by interaction with TTC1Huifang Zhu0Shuang Feng1Sizhen Lv2Di Zhao3Xuanhe Chang4Shangqian Fan5Xia Wang6Xinlai Qian7Department of Pathology, The Third Affiliated Hospital of Xinxiang Medical University, School of Basic Medical Sciences, Xinxiang Medical UniversityDepartment of Pathology, The Third Affiliated Hospital of Xinxiang Medical University, School of Basic Medical Sciences, Xinxiang Medical UniversityDepartment of Pathology, The Third Affiliated Hospital of Xinxiang Medical University, School of Basic Medical Sciences, Xinxiang Medical UniversityDepartment of Pathology, The Third Affiliated Hospital of Xinxiang Medical University, School of Basic Medical Sciences, Xinxiang Medical UniversityThe First Bethune Clinical Medical College of Ji Lin UniversityDepartment of Pathology, The Third Affiliated Hospital of Xinxiang Medical University, School of Basic Medical Sciences, Xinxiang Medical UniversityDepartment of Pathology, The Third Affiliated Hospital of Xinxiang Medical University, School of Basic Medical Sciences, Xinxiang Medical UniversityDepartment of Pathology, The Third Affiliated Hospital of Xinxiang Medical University, School of Basic Medical Sciences, Xinxiang Medical UniversityAbstract Abnormal expression of PGRP-S plays an important role in the development and progression of hepatocellular carcinoma (HCC), although the mechanism has remained elusive. In this study, we aimed to investigate the biological function and potential mechanism of PGRP-S in HCC. We found that PGRP-S was upregulated in HCC tissues compared to adjacent tissues. The increased expression of PGRP-S correlated with the differentiation and lymph node metastasis of HCC. PGRP-S obviously promoted HCC cell proliferation, migration and invasion in vitro. In vivo nude mouse models showed that PGRP-S enhanced tumor growth and pulmonary metastasis. Mechanistically, PGRP-S interacted with TTC1 and activated MAPK/ERK pathway, leading to HCC cell proliferation, migration and invasion. Therfore, our conclusion is PGRP-S promotes HCC cell proliferation, migration and invasion by activating MAPK/ERK pathway, which provides a new potential strategy for HCC treatment by targeting PGRP-S-TTC1 axis.https://doi.org/10.1038/s41598-025-12160-xPGRP-SHepatocellular carcinomaTTC1ProliferationMigration |
| spellingShingle | Huifang Zhu Shuang Feng Sizhen Lv Di Zhao Xuanhe Chang Shangqian Fan Xia Wang Xinlai Qian PGRP-S promotes hepatocellular carcinoma progression via MAPK/ERK pathway by interaction with TTC1 Scientific Reports PGRP-S Hepatocellular carcinoma TTC1 Proliferation Migration |
| title | PGRP-S promotes hepatocellular carcinoma progression via MAPK/ERK pathway by interaction with TTC1 |
| title_full | PGRP-S promotes hepatocellular carcinoma progression via MAPK/ERK pathway by interaction with TTC1 |
| title_fullStr | PGRP-S promotes hepatocellular carcinoma progression via MAPK/ERK pathway by interaction with TTC1 |
| title_full_unstemmed | PGRP-S promotes hepatocellular carcinoma progression via MAPK/ERK pathway by interaction with TTC1 |
| title_short | PGRP-S promotes hepatocellular carcinoma progression via MAPK/ERK pathway by interaction with TTC1 |
| title_sort | pgrp s promotes hepatocellular carcinoma progression via mapk erk pathway by interaction with ttc1 |
| topic | PGRP-S Hepatocellular carcinoma TTC1 Proliferation Migration |
| url | https://doi.org/10.1038/s41598-025-12160-x |
| work_keys_str_mv | AT huifangzhu pgrpspromoteshepatocellularcarcinomaprogressionviamapkerkpathwaybyinteractionwithttc1 AT shuangfeng pgrpspromoteshepatocellularcarcinomaprogressionviamapkerkpathwaybyinteractionwithttc1 AT sizhenlv pgrpspromoteshepatocellularcarcinomaprogressionviamapkerkpathwaybyinteractionwithttc1 AT dizhao pgrpspromoteshepatocellularcarcinomaprogressionviamapkerkpathwaybyinteractionwithttc1 AT xuanhechang pgrpspromoteshepatocellularcarcinomaprogressionviamapkerkpathwaybyinteractionwithttc1 AT shangqianfan pgrpspromoteshepatocellularcarcinomaprogressionviamapkerkpathwaybyinteractionwithttc1 AT xiawang pgrpspromoteshepatocellularcarcinomaprogressionviamapkerkpathwaybyinteractionwithttc1 AT xinlaiqian pgrpspromoteshepatocellularcarcinomaprogressionviamapkerkpathwaybyinteractionwithttc1 |