Gender difference in pre-clinical liver-directed gene therapy with lentiviral vectors

Gender difference in pre-clinical liver-directed gene therapy with lentiviral vectors

Viral vector-based therapies are effective therapeutics for the correction of several disorders, both in mouse models and in humans. Several pre-clinical studies have demonstrated differences in transduction efficiencies and therapeutic effect between male and female mice dosed with AAV-based gene t...

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Bibliographic Details
Main Authors: Efrain Guzman, Cheen Khoo, Deirdre O’Connor, Gayathri Devarajan, Sharifah Iqball, Bernard Souberbielle, Kyriacos Mitrophanous, Yatish Lad
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Experimental Biology and Medicine
Subjects:
lentiviral vectors
adeno-associated virus
AAV
liver
PAH
gender
Online Access:https://www.ebm-journal.org/articles/10.3389/ebm.2025.10422/full
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