Development of a decellularized extracellular matrix-derived wet adhesive for sustained drug delivery and enhanced wound healing
Complete tissue recovery following traumatic injury remains a major clinical challenge. While tissue adhesives show promise for managing traumatic injuries, developing materials with robust wet adhesion and high biocompatibility remains difficult. Decellularized extracellular matrix (ECM)-derived ma...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425002935 |
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| author | Xinming Wang Haonan Zhang Weichang Xie Bei Qian Shixing Huang Qiang Zhao Xiaofeng Ye |
| author_facet | Xinming Wang Haonan Zhang Weichang Xie Bei Qian Shixing Huang Qiang Zhao Xiaofeng Ye |
| author_sort | Xinming Wang |
| collection | DOAJ |
| description | Complete tissue recovery following traumatic injury remains a major clinical challenge. While tissue adhesives show promise for managing traumatic injuries, developing materials with robust wet adhesion and high biocompatibility remains difficult. Decellularized extracellular matrix (ECM)-derived materials are widely utilized in tissue engineering due to their superior biocompatibility and bioactivity. In this study, a wet adhesive is developed by functionalizing ECM with dopamine. The resulting ECM-dopamine exhibits strong wet adhesion and excellent biocompatibility. Furthermore, ECM-dopamine can be engineered into a drug delivery platform for small agents and macromolecules. Solid lipid nanoparticles (SLNs) are incorporated into ECM-dopamine to enable sustained release of small molecules. The ECM-dopamine-SLN system ensures sustained drug release for at least one week upon adhesion to target tissues. ECM-dopamine-SLN loaded with antimicrobials accelerates wound healing and promotes angiogenesis by modulating the inflammatory response in a mouse skin excision model. Additionally, ECM-dopamine can deliver bioactive macromolecules to injured tissue. ECM-dopamine loaded with insulin-like growth factor-1 promotes skeletal muscle regeneration in a mouse volumetric muscle loss model, likely through the modulation of M2-like macrophage polarization. The dual functionality of ECM-dopamine as both a wet adhesive and a drug delivery platform offers significant potential for regenerative medicine applications. |
| format | Article |
| id | doaj-art-06efc9b52b7c407fa99f795c90cc621e |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-06efc9b52b7c407fa99f795c90cc621e2025-08-20T03:17:26ZengElsevierMaterials Today Bio2590-00642025-06-013210173410.1016/j.mtbio.2025.101734Development of a decellularized extracellular matrix-derived wet adhesive for sustained drug delivery and enhanced wound healingXinming Wang0Haonan Zhang1Weichang Xie2Bei Qian3Shixing Huang4Qiang Zhao5Xiaofeng Ye6Corresponding author.; Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaCorresponding author.; Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaCorresponding author.; Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaComplete tissue recovery following traumatic injury remains a major clinical challenge. While tissue adhesives show promise for managing traumatic injuries, developing materials with robust wet adhesion and high biocompatibility remains difficult. Decellularized extracellular matrix (ECM)-derived materials are widely utilized in tissue engineering due to their superior biocompatibility and bioactivity. In this study, a wet adhesive is developed by functionalizing ECM with dopamine. The resulting ECM-dopamine exhibits strong wet adhesion and excellent biocompatibility. Furthermore, ECM-dopamine can be engineered into a drug delivery platform for small agents and macromolecules. Solid lipid nanoparticles (SLNs) are incorporated into ECM-dopamine to enable sustained release of small molecules. The ECM-dopamine-SLN system ensures sustained drug release for at least one week upon adhesion to target tissues. ECM-dopamine-SLN loaded with antimicrobials accelerates wound healing and promotes angiogenesis by modulating the inflammatory response in a mouse skin excision model. Additionally, ECM-dopamine can deliver bioactive macromolecules to injured tissue. ECM-dopamine loaded with insulin-like growth factor-1 promotes skeletal muscle regeneration in a mouse volumetric muscle loss model, likely through the modulation of M2-like macrophage polarization. The dual functionality of ECM-dopamine as both a wet adhesive and a drug delivery platform offers significant potential for regenerative medicine applications.http://www.sciencedirect.com/science/article/pii/S2590006425002935Wet adhesionExtracellular matrix derived-materialDrug deliveryVolumetric muscle lossWound healing |
| spellingShingle | Xinming Wang Haonan Zhang Weichang Xie Bei Qian Shixing Huang Qiang Zhao Xiaofeng Ye Development of a decellularized extracellular matrix-derived wet adhesive for sustained drug delivery and enhanced wound healing Materials Today Bio Wet adhesion Extracellular matrix derived-material Drug delivery Volumetric muscle loss Wound healing |
| title | Development of a decellularized extracellular matrix-derived wet adhesive for sustained drug delivery and enhanced wound healing |
| title_full | Development of a decellularized extracellular matrix-derived wet adhesive for sustained drug delivery and enhanced wound healing |
| title_fullStr | Development of a decellularized extracellular matrix-derived wet adhesive for sustained drug delivery and enhanced wound healing |
| title_full_unstemmed | Development of a decellularized extracellular matrix-derived wet adhesive for sustained drug delivery and enhanced wound healing |
| title_short | Development of a decellularized extracellular matrix-derived wet adhesive for sustained drug delivery and enhanced wound healing |
| title_sort | development of a decellularized extracellular matrix derived wet adhesive for sustained drug delivery and enhanced wound healing |
| topic | Wet adhesion Extracellular matrix derived-material Drug delivery Volumetric muscle loss Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425002935 |
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