Biology and Application of <i>Chaetomium globosum</i> as a Biocontrol Agent: Current Status and Future Prospects

<i>Chaetomium globosum</i> is a widely distributed fungal species recognized for its ability to produce a range of secondary metabolites. This fungus plays a significant ecological role by degrading organic matter and contributing to nutrient cycling in diverse ecosystems. In recent year...

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Bibliographic Details
Main Authors: Shailja Sharma, Saurabh Pandey, Sourabh Kulshreshtha, Mukesh Dubey
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Microorganisms
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Online Access:https://www.mdpi.com/2076-2607/13/7/1646
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Summary:<i>Chaetomium globosum</i> is a widely distributed fungal species recognized for its ability to produce a range of secondary metabolites. This fungus plays a significant ecological role by degrading organic matter and contributing to nutrient cycling in diverse ecosystems. In recent years, <i>C. globosum</i> has attracted considerable scientific interest due to its potential as a biocontrol agent [BCA] against a wide array of diseases in numerous plant species. While the precise mechanisms of <i>C. globosum</i> as a BCA remain poorly understood, interference competition through antibiosis is one of the key mechanisms. Moreover, <i>C. globosum</i> can enhance plant health by promoting nutrient availability, manipulating the rhizosphere microbiome, and inducing plant defense responses. The formulation of <i>C. globosum</i> for agricultural applications has been reported, which can significantly improve stability and efficacy under field conditions. However, despite significant advancements in omics and molecular biology technologies, the biology of <i>C. globosum</i> is understudied. Enhanced research into the genetics and functional genomics of <i>C. globosum</i> could pave the way for its applications in sustainable agriculture. This review summarizes the role of <i>C. globosum</i> as a BCA, focusing on its underlying mechanisms such as genomics and transcriptomics, and the effects of <i>C. globosum</i> application on soil health and the rhizosphere microbiome.
ISSN:2076-2607