SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters1

SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters1

Prevention of robust severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in nasal turbinate (NT) requires in vivo evaluation of IgA neutralizing antibodies. Here, we report the efficacy of receptor binding domain (RBD)-specific monomeric B8-mIgA1 and B8-mIgA2, and dimeric B8-dIgA1...

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Main Authors: Biao Zhou, Runhong Zhou, Jasper Fuk-Woo Chan, Jianwei Zeng, Qi Zhang, Shuofeng Yuan, Li Liu, Rémy Robinot, Sisi Shan, Na Liu, Jiwan Ge, Hugo Yat-Hei Kwong, Dongyan Zhou, Haoran Xu, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Hin Chu, Ming Yue, Ka-Yi Kwan, Chun-Yin Chan, Chris Chun-Yiu Chan, Kenn Ka-Heng Chik, Zhenglong Du, Ka-Kit Au, Haode Huang, Hiu-On Man, Jianli Cao, Cun Li, Ziyi Wang, Jie Zhou, Youqiang Song, Man-Lung Yeung, Kelvin Kai-Wang To, David D. Ho, Lisa A. Chakrabarti, Xinquan Wang, Linqi Zhang, Kwok-Yung Yuen, Zhiwei Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
SARS-CoV-2
neutralizing antibody
IgA
nasal turbinate
antibody-mediated trans-infection
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2245921
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