Development of Low-Dose Disulfiram Rectal Suppository Intended for Application in Post-Treatment Lyme Disease Syndrome

Development of Low-Dose Disulfiram Rectal Suppository Intended for Application in Post-Treatment Lyme Disease Syndrome

<b>Background/Objectives</b>: Early diagnosis and oral or, in severe cases, intravenous antibiotics are usually effective for Lyme disease, but some patients have persistent symptoms unresponsive to standards of care, requiring alternative therapies. Disulfiram (DIS), a drug for alcoholi...

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Main Authors: Beáta-Mária Benkő, Bálint-Imre Szabó, Szabina Kádár, Edina Szabó, Gergő Tóth, Lajos Szente, Péter Tonka-Nagy, Romána Zelkó, István Sebe
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceutics
Subjects:
disulfiram
Lyme disease
cyclodextrin
polyethylene glycol
rectal suppository
Online Access:https://www.mdpi.com/1999-4923/17/7/849
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