Using sodium glycodeoxycholate to develop a temporary infant-like gut barrier model, in vitro

Using sodium glycodeoxycholate to develop a temporary infant-like gut barrier model, in vitro

IntroductionIn newborns, the intestinal barrier is permeable but not inflamed. Understanding this unique state is essential for developing models relevant to infant gut physiology.MethodsThis study aimed to develop an in vitro model of the infant gut barrier treating Caco-2/HT29-MTX with 0.5, 0.8, a...

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Bibliographic Details
Main Authors: Francesca Bietto, Elena Arranz, Beatriz Miralles, Cristina Gómez-Marín, Eva Rath, Alice J. Lucey, Linda Giblin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Nutrition
Subjects:
in vitro infant gut barrier
sodium glycodeoxycholate
Caco-2/HT29-MTX
tight junctions
intestinal permeability
TEER
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1577369/full
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