Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization

Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization

ABSTRACT Absolute bacterial biomass estimation in the human gut is crucial for understanding microbiome dynamics and host-microbe interactions. Current methods for quantifying bacterial biomass in stool, such as flow cytometry, quantitative polymerase chain reaction (qPCR), or spike-ins, can be labo...

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Bibliographic Details
Main Authors: Gechlang Tang, Alex V. Carr, Crystal Perez, Katherine Ramos Sarmiento, Lisa Levy, Johanna W. Lampe, Christian Diener, Sean M. Gibbons
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mSystems
Subjects:
metagenomics
human microbiome
gut microbiome
absolute biomass
host DNA
diet DNA
Online Access:https://journals.asm.org/doi/10.1128/msystems.00984-25
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