A scoping review of robustness concepts for machine learning in healthcare

Abstract While machine learning (ML)-based solutions—often referred to as artificial intelligence (AI) solutions—have demonstrated comparable or superior performance to human experts across various healthcare applications, their vulnerability to perturbations and stability to variations due to new e...

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Main Authors: Alan Balendran, Céline Beji, Florie Bouvier, Ottavio Khalifa, Theodoros Evgeniou, Philippe Ravaud, Raphaël Porcher
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:npj Digital Medicine
Online Access:https://doi.org/10.1038/s41746-024-01420-1
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author Alan Balendran
Céline Beji
Florie Bouvier
Ottavio Khalifa
Theodoros Evgeniou
Philippe Ravaud
Raphaël Porcher
author_facet Alan Balendran
Céline Beji
Florie Bouvier
Ottavio Khalifa
Theodoros Evgeniou
Philippe Ravaud
Raphaël Porcher
author_sort Alan Balendran
collection DOAJ
description Abstract While machine learning (ML)-based solutions—often referred to as artificial intelligence (AI) solutions—have demonstrated comparable or superior performance to human experts across various healthcare applications, their vulnerability to perturbations and stability to variations due to new environments—essentially, their robustness—remains ambiguous and often overlooked. In this review, we aimed to identify the types of robustness addressed in the literature for ML models in healthcare. A total of 274 eligible records were retrieved from PubMed, Web of Science, IEEE Xplore, and additional sources. Eight general concepts of robustness emerged. Furthermore, an analysis of those concepts across types of data and types of predictive models revealed that the concepts were differently addressed. Our findings offer valuable insights for stakeholders seeking to understand and navigate the robustness of machine learning models during their development, validation, and deployment in healthcare settings, where interpretation of robustness may vary.
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spelling doaj-art-06e0727fc2ae4fe7a2f6deada5a52d1c2025-01-19T12:39:44ZengNature Portfolionpj Digital Medicine2398-63522025-01-01811910.1038/s41746-024-01420-1A scoping review of robustness concepts for machine learning in healthcareAlan Balendran0Céline Beji1Florie Bouvier2Ottavio Khalifa3Theodoros Evgeniou4Philippe Ravaud5Raphaël Porcher6Université Paris Cité, Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS)Université Paris Cité, Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS)Université Paris Cité, Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS)Université Paris Cité, Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS)INSEAD Decision SciencesUniversité Paris Cité, Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS)Université Paris Cité, Université Sorbonne Paris Nord, INSERM, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS)Abstract While machine learning (ML)-based solutions—often referred to as artificial intelligence (AI) solutions—have demonstrated comparable or superior performance to human experts across various healthcare applications, their vulnerability to perturbations and stability to variations due to new environments—essentially, their robustness—remains ambiguous and often overlooked. In this review, we aimed to identify the types of robustness addressed in the literature for ML models in healthcare. A total of 274 eligible records were retrieved from PubMed, Web of Science, IEEE Xplore, and additional sources. Eight general concepts of robustness emerged. Furthermore, an analysis of those concepts across types of data and types of predictive models revealed that the concepts were differently addressed. Our findings offer valuable insights for stakeholders seeking to understand and navigate the robustness of machine learning models during their development, validation, and deployment in healthcare settings, where interpretation of robustness may vary.https://doi.org/10.1038/s41746-024-01420-1
spellingShingle Alan Balendran
Céline Beji
Florie Bouvier
Ottavio Khalifa
Theodoros Evgeniou
Philippe Ravaud
Raphaël Porcher
A scoping review of robustness concepts for machine learning in healthcare
npj Digital Medicine
title A scoping review of robustness concepts for machine learning in healthcare
title_full A scoping review of robustness concepts for machine learning in healthcare
title_fullStr A scoping review of robustness concepts for machine learning in healthcare
title_full_unstemmed A scoping review of robustness concepts for machine learning in healthcare
title_short A scoping review of robustness concepts for machine learning in healthcare
title_sort scoping review of robustness concepts for machine learning in healthcare
url https://doi.org/10.1038/s41746-024-01420-1
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