Recent Findings on the Role of Gelatinases (Matrix Metalloproteinase-2 and -9) in Osteoarthritis
Several studies dealing with the pathomechanisms of OA refer to MMP-1, -3, -7, -8, and -13 whereas a smaller number of investigations have pointed out the pathogenic role of gelatinases in OA. These gelatinases are best known for their involvement in pulmonary, myocardial, and neoplastic disease but...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Orthopedics |
| Online Access: | http://dx.doi.org/10.1155/2012/834208 |
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| _version_ | 1849305542702399488 |
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| author | Olimpio Galasso Filippo Familiari Marco De Gori Giorgio Gasparini |
| author_facet | Olimpio Galasso Filippo Familiari Marco De Gori Giorgio Gasparini |
| author_sort | Olimpio Galasso |
| collection | DOAJ |
| description | Several studies dealing with the pathomechanisms of OA refer to MMP-1, -3, -7, -8, and -13 whereas a smaller number of investigations have pointed out the pathogenic role of gelatinases in OA. These gelatinases are best known for their involvement in pulmonary, myocardial, and neoplastic disease but they are emerging as important proteases implicated in the OA progression. This paper highlights the role of the gelatinases as emerging factors in OA pathogenesis through the regulation of subchondral bone resorption and microvascular invasion. The most significant new findings over the last year that add to our knowledge of the activity of these proteins in OA have been reported. |
| format | Article |
| id | doaj-art-06dcbf19facd4debb41a9e084a865522 |
| institution | Kabale University |
| issn | 2090-3464 2090-3472 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Orthopedics |
| spelling | doaj-art-06dcbf19facd4debb41a9e084a8655222025-08-20T03:55:24ZengWileyAdvances in Orthopedics2090-34642090-34722012-01-01201210.1155/2012/834208834208Recent Findings on the Role of Gelatinases (Matrix Metalloproteinase-2 and -9) in OsteoarthritisOlimpio Galasso0Filippo Familiari1Marco De Gori2Giorgio Gasparini3Department of Orthopaedic and Trauma Surgery, School of Medicine, University Magna Græcia of Catanzaro, Europa Avenue, 88100 Catanzaro, ItalyDepartment of Orthopaedic and Trauma Surgery, School of Medicine, University Magna Græcia of Catanzaro, Europa Avenue, 88100 Catanzaro, ItalyDepartment of Orthopaedic and Trauma Surgery, School of Medicine, University Magna Græcia of Catanzaro, Europa Avenue, 88100 Catanzaro, ItalyDepartment of Orthopaedic and Trauma Surgery, School of Medicine, University Magna Græcia of Catanzaro, Europa Avenue, 88100 Catanzaro, ItalySeveral studies dealing with the pathomechanisms of OA refer to MMP-1, -3, -7, -8, and -13 whereas a smaller number of investigations have pointed out the pathogenic role of gelatinases in OA. These gelatinases are best known for their involvement in pulmonary, myocardial, and neoplastic disease but they are emerging as important proteases implicated in the OA progression. This paper highlights the role of the gelatinases as emerging factors in OA pathogenesis through the regulation of subchondral bone resorption and microvascular invasion. The most significant new findings over the last year that add to our knowledge of the activity of these proteins in OA have been reported.http://dx.doi.org/10.1155/2012/834208 |
| spellingShingle | Olimpio Galasso Filippo Familiari Marco De Gori Giorgio Gasparini Recent Findings on the Role of Gelatinases (Matrix Metalloproteinase-2 and -9) in Osteoarthritis Advances in Orthopedics |
| title | Recent Findings on the Role of Gelatinases (Matrix Metalloproteinase-2 and -9) in Osteoarthritis |
| title_full | Recent Findings on the Role of Gelatinases (Matrix Metalloproteinase-2 and -9) in Osteoarthritis |
| title_fullStr | Recent Findings on the Role of Gelatinases (Matrix Metalloproteinase-2 and -9) in Osteoarthritis |
| title_full_unstemmed | Recent Findings on the Role of Gelatinases (Matrix Metalloproteinase-2 and -9) in Osteoarthritis |
| title_short | Recent Findings on the Role of Gelatinases (Matrix Metalloproteinase-2 and -9) in Osteoarthritis |
| title_sort | recent findings on the role of gelatinases matrix metalloproteinase 2 and 9 in osteoarthritis |
| url | http://dx.doi.org/10.1155/2012/834208 |
| work_keys_str_mv | AT olimpiogalasso recentfindingsontheroleofgelatinasesmatrixmetalloproteinase2and9inosteoarthritis AT filippofamiliari recentfindingsontheroleofgelatinasesmatrixmetalloproteinase2and9inosteoarthritis AT marcodegori recentfindingsontheroleofgelatinasesmatrixmetalloproteinase2and9inosteoarthritis AT giorgiogasparini recentfindingsontheroleofgelatinasesmatrixmetalloproteinase2and9inosteoarthritis |