Paradigm shifts in neonatal hypoxic-ischemic encephalopathy therapeutics: a four-decade bibliometric exploration of emerging therapeutic dimensions (1985–2024)
AimNeonatal hypoxic-ischemic encephalopathy (HIE) remains a significant cause of neonatal morbidity and mortality worldwide, necessitating the exploration of effective therapeutic interventions. Current treatment strategies primarily involve therapeutic hypothermia (TH); however, its efficacy remain...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1611345/full |
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| author | Juntao Shu Ling Liu Mei Yuan Mingbiao Ma Jingjing Yang |
| author_facet | Juntao Shu Ling Liu Mei Yuan Mingbiao Ma Jingjing Yang |
| author_sort | Juntao Shu |
| collection | DOAJ |
| description | AimNeonatal hypoxic-ischemic encephalopathy (HIE) remains a significant cause of neonatal morbidity and mortality worldwide, necessitating the exploration of effective therapeutic interventions. Current treatment strategies primarily involve therapeutic hypothermia (TH); however, its efficacy remains inconsistent. Research topics and trends in this area remain unclear as well. This study aimed to identify key research areas, collaboration networks, and emerging trends using bibliometric analysis tools.MethodsA comprehensive analysis was conducted on 1,165 records from the Web of Science Core Collection (WoSCC) database. Various bibliometric techniques were employed, including coauthor analysis, co-occurrence analysis, co-citation analysis, reference clustering, and topic modeling, to visualize the knowledge structure and research dynamics in the HIE field.ResultsThe findings revealed extensive collaboration networks among authors, institutions, and countries, highlighting global efforts to address this critical neonatal condition. Recent trends identified key research areas, including TH, mild systemic hypothermia, oxidative stress, biomarkers and signaling pathways, which are essential for advancing the understanding and treatment of HIE.ConclusionThis study provides valuable insights into the current TH for neonates with HIE. Future research should focus on optimizing treatment approaches and evaluating long-term efficacy to enhance clinical applications. |
| format | Article |
| id | doaj-art-06d6d5443bda446dbfef3351a3cffa73 |
| institution | DOAJ |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-06d6d5443bda446dbfef3351a3cffa732025-08-20T02:48:54ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-07-011310.3389/fped.2025.16113451611345Paradigm shifts in neonatal hypoxic-ischemic encephalopathy therapeutics: a four-decade bibliometric exploration of emerging therapeutic dimensions (1985–2024)Juntao Shu0Ling Liu1Mei Yuan2Mingbiao Ma3Jingjing Yang4Department of Neonatology, The Children’s Hospital of Kunming City, The Affiliated Children’s Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Neonatology, The Children’s Hospital of Kunming City, The Affiliated Children’s Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Clinical Laboratory, The Children’s Hospital of Kunming City, The Affiliated Children’s Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Clinical Laboratory, The Children’s Hospital of Kunming City, The Affiliated Children’s Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Geriatric, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, ChinaAimNeonatal hypoxic-ischemic encephalopathy (HIE) remains a significant cause of neonatal morbidity and mortality worldwide, necessitating the exploration of effective therapeutic interventions. Current treatment strategies primarily involve therapeutic hypothermia (TH); however, its efficacy remains inconsistent. Research topics and trends in this area remain unclear as well. This study aimed to identify key research areas, collaboration networks, and emerging trends using bibliometric analysis tools.MethodsA comprehensive analysis was conducted on 1,165 records from the Web of Science Core Collection (WoSCC) database. Various bibliometric techniques were employed, including coauthor analysis, co-occurrence analysis, co-citation analysis, reference clustering, and topic modeling, to visualize the knowledge structure and research dynamics in the HIE field.ResultsThe findings revealed extensive collaboration networks among authors, institutions, and countries, highlighting global efforts to address this critical neonatal condition. Recent trends identified key research areas, including TH, mild systemic hypothermia, oxidative stress, biomarkers and signaling pathways, which are essential for advancing the understanding and treatment of HIE.ConclusionThis study provides valuable insights into the current TH for neonates with HIE. Future research should focus on optimizing treatment approaches and evaluating long-term efficacy to enhance clinical applications.https://www.frontiersin.org/articles/10.3389/fped.2025.1611345/fulltherapeutic hypothermiahypoxic-ischemic encephalopathybiomarkerssignaling pathwaysemerging treatmentsbibliometric analysis |
| spellingShingle | Juntao Shu Ling Liu Mei Yuan Mingbiao Ma Jingjing Yang Paradigm shifts in neonatal hypoxic-ischemic encephalopathy therapeutics: a four-decade bibliometric exploration of emerging therapeutic dimensions (1985–2024) Frontiers in Pediatrics therapeutic hypothermia hypoxic-ischemic encephalopathy biomarkers signaling pathways emerging treatments bibliometric analysis |
| title | Paradigm shifts in neonatal hypoxic-ischemic encephalopathy therapeutics: a four-decade bibliometric exploration of emerging therapeutic dimensions (1985–2024) |
| title_full | Paradigm shifts in neonatal hypoxic-ischemic encephalopathy therapeutics: a four-decade bibliometric exploration of emerging therapeutic dimensions (1985–2024) |
| title_fullStr | Paradigm shifts in neonatal hypoxic-ischemic encephalopathy therapeutics: a four-decade bibliometric exploration of emerging therapeutic dimensions (1985–2024) |
| title_full_unstemmed | Paradigm shifts in neonatal hypoxic-ischemic encephalopathy therapeutics: a four-decade bibliometric exploration of emerging therapeutic dimensions (1985–2024) |
| title_short | Paradigm shifts in neonatal hypoxic-ischemic encephalopathy therapeutics: a four-decade bibliometric exploration of emerging therapeutic dimensions (1985–2024) |
| title_sort | paradigm shifts in neonatal hypoxic ischemic encephalopathy therapeutics a four decade bibliometric exploration of emerging therapeutic dimensions 1985 2024 |
| topic | therapeutic hypothermia hypoxic-ischemic encephalopathy biomarkers signaling pathways emerging treatments bibliometric analysis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1611345/full |
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