Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster
As the early step of food ingestion, the swallow is under rigorous sensorimotor control. Nevertheless, the mechanisms underlying swallow control at a molecular and circuitry level remain largely unknown. Here, we find that mutation of the mechanotransduction channel genes nompC, Tmc, or piezo impair...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2024-12-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/88614 |
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| author | Jierui Qin Tingting Yang Kexin Li Ting Liu Wei Zhang |
| author_facet | Jierui Qin Tingting Yang Kexin Li Ting Liu Wei Zhang |
| author_sort | Jierui Qin |
| collection | DOAJ |
| description | As the early step of food ingestion, the swallow is under rigorous sensorimotor control. Nevertheless, the mechanisms underlying swallow control at a molecular and circuitry level remain largely unknown. Here, we find that mutation of the mechanotransduction channel genes nompC, Tmc, or piezo impairs the regular pumping rhythm of the cibarium during feeding of the fruit fly Drosophila melanogaster. A group of multi-dendritic mechanosensory neurons, which co-express the three channels, wrap the cibarium and are crucial for coordinating the filling and emptying of the cibarium. Inhibition of them causes difficulty in food emptying in the cibarium, while their activation leads to difficulty in cibarium filling. Synaptic and functional connections are detected between the pharyngeal mechanosensory neurons and the motor circuit that controls swallow. This study elucidates the role of mechanosensation in swallow, and provides insights for a better understanding of the neural basis of food swallow. |
| format | Article |
| id | doaj-art-06d0fc51ab6e4df2a838011b83f0f847 |
| institution | OA Journals |
| issn | 2050-084X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-06d0fc51ab6e4df2a838011b83f0f8472025-08-20T02:36:41ZengeLife Sciences Publications LtdeLife2050-084X2024-12-011210.7554/eLife.88614Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogasterJierui Qin0https://orcid.org/0009-0006-8197-1715Tingting Yang1Kexin Li2Ting Liu3Wei Zhang4https://orcid.org/0000-0003-0512-3096School of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China; Tsinghua-Peking Center for Life Science, Beijing, ChinaSchool of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China; Tsinghua-Peking Center for Life Science, Beijing, ChinaSchool of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China; Tsinghua-Peking Center for Life Science, Beijing, ChinaSchool of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, ChinaTsinghua-Peking Center for Life Science, Beijing, ChinaAs the early step of food ingestion, the swallow is under rigorous sensorimotor control. Nevertheless, the mechanisms underlying swallow control at a molecular and circuitry level remain largely unknown. Here, we find that mutation of the mechanotransduction channel genes nompC, Tmc, or piezo impairs the regular pumping rhythm of the cibarium during feeding of the fruit fly Drosophila melanogaster. A group of multi-dendritic mechanosensory neurons, which co-express the three channels, wrap the cibarium and are crucial for coordinating the filling and emptying of the cibarium. Inhibition of them causes difficulty in food emptying in the cibarium, while their activation leads to difficulty in cibarium filling. Synaptic and functional connections are detected between the pharyngeal mechanosensory neurons and the motor circuit that controls swallow. This study elucidates the role of mechanosensation in swallow, and provides insights for a better understanding of the neural basis of food swallow.https://elifesciences.org/articles/88614feedingmechanosensationswallowDrosophila |
| spellingShingle | Jierui Qin Tingting Yang Kexin Li Ting Liu Wei Zhang Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster eLife feeding mechanosensation swallow Drosophila |
| title | Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster |
| title_full | Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster |
| title_fullStr | Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster |
| title_full_unstemmed | Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster |
| title_short | Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster |
| title_sort | pharyngeal mechanosensory neurons control food swallow in drosophila melanogaster |
| topic | feeding mechanosensation swallow Drosophila |
| url | https://elifesciences.org/articles/88614 |
| work_keys_str_mv | AT jieruiqin pharyngealmechanosensoryneuronscontrolfoodswallowindrosophilamelanogaster AT tingtingyang pharyngealmechanosensoryneuronscontrolfoodswallowindrosophilamelanogaster AT kexinli pharyngealmechanosensoryneuronscontrolfoodswallowindrosophilamelanogaster AT tingliu pharyngealmechanosensoryneuronscontrolfoodswallowindrosophilamelanogaster AT weizhang pharyngealmechanosensoryneuronscontrolfoodswallowindrosophilamelanogaster |