Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts
Background. More than 90% of human immunodeficiency virus- (HIV-) infected patients show at least one mucocutaneous manifestation during the course of their disease. The frequency, pattern, and associated factors of these complications vary among different populations. Objective. This study was plan...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2020/7503756 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850233776144121856 |
|---|---|
| author | Mina Mirnezami Nader Zarinfar Masoomeh Sofian Bahareh Botlani Yadegar Hoda Rahimi |
| author_facet | Mina Mirnezami Nader Zarinfar Masoomeh Sofian Bahareh Botlani Yadegar Hoda Rahimi |
| author_sort | Mina Mirnezami |
| collection | DOAJ |
| description | Background. More than 90% of human immunodeficiency virus- (HIV-) infected patients show at least one mucocutaneous manifestation during the course of their disease. The frequency, pattern, and associated factors of these complications vary among different populations. Objective. This study was planned to evaluate the frequency of cutaneous presentations in HIV-infected patients and their association with the count of CD4 cells. Methods. A cross-sectional study was conducted on eighty-four HIV-positive patients, who attended the Behavior Consultation Center of Arak University of Medical Sciences. All subjects had a complete physical examination by an expert dermatologist. Further diagnostic procedures were performed, if necessary. Counts of CD4 were determined using flow cytometry. Results. From 84 patients who enrolled in this study, 95.2% manifested at least one type of mucocutaneous lesions. The most common presentation was xerosis, followed by seborrheic dermatitis, herpes simplex, and oral candidiasis. Oral candidiasis and furuncle were significantly associated with decrease in CD4 cell counts. Conclusions. Cutaneous manifestations are common in HIV-positive patients, some of which (oral candidiasis and furuncle) could be applicable as useful clinical indicators to predict the immune status of the patients. Therefore, regular skin examinations are recommended as routine HIV-infected patients’ healthcare programs. |
| format | Article |
| id | doaj-art-06d086a79e8d4c32909c52853ec7c105 |
| institution | OA Journals |
| issn | 2090-908X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-06d086a79e8d4c32909c52853ec7c1052025-08-20T02:02:51ZengWileyScientifica2090-908X2020-01-01202010.1155/2020/75037567503756Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte CountsMina Mirnezami0Nader Zarinfar1Masoomeh Sofian2Bahareh Botlani Yadegar3Hoda Rahimi4Department of Dermatology, Faculty of Medicine, Arak University of Medical Sciences, Arak, IranDepartment of Infectious Diseases, Arak University of Medical Sciences, Arak, IranDepartment of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, IranSkin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground. More than 90% of human immunodeficiency virus- (HIV-) infected patients show at least one mucocutaneous manifestation during the course of their disease. The frequency, pattern, and associated factors of these complications vary among different populations. Objective. This study was planned to evaluate the frequency of cutaneous presentations in HIV-infected patients and their association with the count of CD4 cells. Methods. A cross-sectional study was conducted on eighty-four HIV-positive patients, who attended the Behavior Consultation Center of Arak University of Medical Sciences. All subjects had a complete physical examination by an expert dermatologist. Further diagnostic procedures were performed, if necessary. Counts of CD4 were determined using flow cytometry. Results. From 84 patients who enrolled in this study, 95.2% manifested at least one type of mucocutaneous lesions. The most common presentation was xerosis, followed by seborrheic dermatitis, herpes simplex, and oral candidiasis. Oral candidiasis and furuncle were significantly associated with decrease in CD4 cell counts. Conclusions. Cutaneous manifestations are common in HIV-positive patients, some of which (oral candidiasis and furuncle) could be applicable as useful clinical indicators to predict the immune status of the patients. Therefore, regular skin examinations are recommended as routine HIV-infected patients’ healthcare programs.http://dx.doi.org/10.1155/2020/7503756 |
| spellingShingle | Mina Mirnezami Nader Zarinfar Masoomeh Sofian Bahareh Botlani Yadegar Hoda Rahimi Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts Scientifica |
| title | Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts |
| title_full | Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts |
| title_fullStr | Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts |
| title_full_unstemmed | Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts |
| title_short | Mucocutaneous Manifestations in HIV-Infected Patients and Their Relationship to CD4 Lymphocyte Counts |
| title_sort | mucocutaneous manifestations in hiv infected patients and their relationship to cd4 lymphocyte counts |
| url | http://dx.doi.org/10.1155/2020/7503756 |
| work_keys_str_mv | AT minamirnezami mucocutaneousmanifestationsinhivinfectedpatientsandtheirrelationshiptocd4lymphocytecounts AT naderzarinfar mucocutaneousmanifestationsinhivinfectedpatientsandtheirrelationshiptocd4lymphocytecounts AT masoomehsofian mucocutaneousmanifestationsinhivinfectedpatientsandtheirrelationshiptocd4lymphocytecounts AT baharehbotlaniyadegar mucocutaneousmanifestationsinhivinfectedpatientsandtheirrelationshiptocd4lymphocytecounts AT hodarahimi mucocutaneousmanifestationsinhivinfectedpatientsandtheirrelationshiptocd4lymphocytecounts |