Advances in nanotechnology for the therapy of bacterial pneumonia
Bacterial pneumonia, a life-threatening infection, is the world’s sixth deadliest disease and the top cause of mortality in children under five. Without timely treatment, bacterial pneumonia can escalate to a 30% mortality rate, particularly in high-risk populations. It may also lead to chronic cond...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1639783/full |
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| author | Zihan Tian Zihan Tian Yuwei Zhang Jiachen Yun Weihong Kuang Weihong Kuang Jin Li |
| author_facet | Zihan Tian Zihan Tian Yuwei Zhang Jiachen Yun Weihong Kuang Weihong Kuang Jin Li |
| author_sort | Zihan Tian |
| collection | DOAJ |
| description | Bacterial pneumonia, a life-threatening infection, is the world’s sixth deadliest disease and the top cause of mortality in children under five. Without timely treatment, bacterial pneumonia can escalate to a 30% mortality rate, particularly in high-risk populations. It may also lead to chronic conditions such as pulmonary fibrosis and chronic obstructive pulmonary disease(COPD), along with systemic inflammatory responses that can progress to sepsis and multi-organ failure. Although antibiotics are generally effective against bacterial pneumonia, current treatment approaches remain insufficient due to several barriers, including the lung’s unique mucus barrier, low pH, high oxidative stress, disruption of alveolar surfactants, and accumulation of hypertonic fluid on the airway surface. In addition, following the excessive use of antibiotics, dysbiosis, secondary infections and resistance occur. Nanomaterials can be an effective way to improve therapeutic effects owing to their change on drug size, physicochemical properties, hydrophobicity along with better targeting ability, and controlled localized release. Organic and inorganic substances and their composites are the three main types of nanomaterials to treat bacterial pneumonia. This review presents the latest advancements and constraints of these nanomaterials from a nanotechnology viewpoint with a view to developing therapeutic strategies for bacterial pneumonia. |
| format | Article |
| id | doaj-art-06cce1f9abf14c4ebd5b248d1135a8e8 |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-06cce1f9abf14c4ebd5b248d1135a8e82025-08-20T02:48:53ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-07-011510.3389/fcimb.2025.16397831639783Advances in nanotechnology for the therapy of bacterial pneumoniaZihan Tian0Zihan Tian1Yuwei Zhang2Jiachen Yun3Weihong Kuang4Weihong Kuang5Jin Li6Mental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Geriatric, Chengdu Second People’s Hospital, Chengdu, ChinaWest China Fourth Hospital, Chengdu, ChinaMental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaNational Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaMental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaBacterial pneumonia, a life-threatening infection, is the world’s sixth deadliest disease and the top cause of mortality in children under five. Without timely treatment, bacterial pneumonia can escalate to a 30% mortality rate, particularly in high-risk populations. It may also lead to chronic conditions such as pulmonary fibrosis and chronic obstructive pulmonary disease(COPD), along with systemic inflammatory responses that can progress to sepsis and multi-organ failure. Although antibiotics are generally effective against bacterial pneumonia, current treatment approaches remain insufficient due to several barriers, including the lung’s unique mucus barrier, low pH, high oxidative stress, disruption of alveolar surfactants, and accumulation of hypertonic fluid on the airway surface. In addition, following the excessive use of antibiotics, dysbiosis, secondary infections and resistance occur. Nanomaterials can be an effective way to improve therapeutic effects owing to their change on drug size, physicochemical properties, hydrophobicity along with better targeting ability, and controlled localized release. Organic and inorganic substances and their composites are the three main types of nanomaterials to treat bacterial pneumonia. This review presents the latest advancements and constraints of these nanomaterials from a nanotechnology viewpoint with a view to developing therapeutic strategies for bacterial pneumonia.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1639783/fullnanotechnologydrug delivery systemsorganic nanomaterialsinorganic nanomaterialbacterial pneumonia |
| spellingShingle | Zihan Tian Zihan Tian Yuwei Zhang Jiachen Yun Weihong Kuang Weihong Kuang Jin Li Advances in nanotechnology for the therapy of bacterial pneumonia Frontiers in Cellular and Infection Microbiology nanotechnology drug delivery systems organic nanomaterials inorganic nanomaterial bacterial pneumonia |
| title | Advances in nanotechnology for the therapy of bacterial pneumonia |
| title_full | Advances in nanotechnology for the therapy of bacterial pneumonia |
| title_fullStr | Advances in nanotechnology for the therapy of bacterial pneumonia |
| title_full_unstemmed | Advances in nanotechnology for the therapy of bacterial pneumonia |
| title_short | Advances in nanotechnology for the therapy of bacterial pneumonia |
| title_sort | advances in nanotechnology for the therapy of bacterial pneumonia |
| topic | nanotechnology drug delivery systems organic nanomaterials inorganic nanomaterial bacterial pneumonia |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1639783/full |
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