Ropivacaine Plasma Concentrations after 192-Hour High Dose Epidural Ropivacaine Infusion in a Pediatric Patient without Side Effects
This case report discusses continuous epidural administration of ropivacaine 0.56 mg kg−1 h −1 for 8 days in a 7-year-old trauma patient to prevent pain, after performing a lower right and upper left leg guillotine amputation. Venous sampling after 8 days revealed bound and unbound ropivacaine conce...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Anesthesiology |
| Online Access: | http://dx.doi.org/10.1155/2018/9150980 |
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| author | Glenn van de Vossenberg Selina van der Wal Andrea Müller Edward Tan Kris Vissers |
| author_facet | Glenn van de Vossenberg Selina van der Wal Andrea Müller Edward Tan Kris Vissers |
| author_sort | Glenn van de Vossenberg |
| collection | DOAJ |
| description | This case report discusses continuous epidural administration of ropivacaine 0.56 mg kg−1 h −1 for 8 days in a 7-year-old trauma patient to prevent pain, after performing a lower right and upper left leg guillotine amputation. Venous sampling after 8 days revealed bound and unbound ropivacaine concentrations of 1.1 mg/l and 0.06 mg/l in plasma, respectively. Arterial sampling for bound and unbound ropivacaine was 1.2 mg/l and 0.05 mg/l in plasma, respectively. In this case report, long-term high dose epidural infiltration of ropivacaine did not result in severe side effects or complications. Further studies are needed to explore safety of these concentrations in larger populations of children. |
| format | Article |
| id | doaj-art-06cc7a3549ee4cb392ffa7e72979180d |
| institution | Kabale University |
| issn | 2090-6382 2090-6390 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Anesthesiology |
| spelling | doaj-art-06cc7a3549ee4cb392ffa7e72979180d2025-08-20T03:55:24ZengWileyCase Reports in Anesthesiology2090-63822090-63902018-01-01201810.1155/2018/91509809150980Ropivacaine Plasma Concentrations after 192-Hour High Dose Epidural Ropivacaine Infusion in a Pediatric Patient without Side EffectsGlenn van de Vossenberg0Selina van der Wal1Andrea Müller2Edward Tan3Kris Vissers4Department of Anesthesiology, Pain and Palliative Medicine, Radboudumc, Nijmegen, NetherlandsDepartment of Anesthesiology, Pain and Palliative Medicine, Radboudumc, Nijmegen, NetherlandsDepartment of Anesthesiology, Pain and Palliative Medicine, Radboudumc, Nijmegen, NetherlandsDepartment of Surgery, Radboudumc, NetherlandsDepartment of Anesthesiology, Pain and Palliative Medicine, Radboudumc, Nijmegen, NetherlandsThis case report discusses continuous epidural administration of ropivacaine 0.56 mg kg−1 h −1 for 8 days in a 7-year-old trauma patient to prevent pain, after performing a lower right and upper left leg guillotine amputation. Venous sampling after 8 days revealed bound and unbound ropivacaine concentrations of 1.1 mg/l and 0.06 mg/l in plasma, respectively. Arterial sampling for bound and unbound ropivacaine was 1.2 mg/l and 0.05 mg/l in plasma, respectively. In this case report, long-term high dose epidural infiltration of ropivacaine did not result in severe side effects or complications. Further studies are needed to explore safety of these concentrations in larger populations of children.http://dx.doi.org/10.1155/2018/9150980 |
| spellingShingle | Glenn van de Vossenberg Selina van der Wal Andrea Müller Edward Tan Kris Vissers Ropivacaine Plasma Concentrations after 192-Hour High Dose Epidural Ropivacaine Infusion in a Pediatric Patient without Side Effects Case Reports in Anesthesiology |
| title | Ropivacaine Plasma Concentrations after 192-Hour High Dose Epidural Ropivacaine Infusion in a Pediatric Patient without Side Effects |
| title_full | Ropivacaine Plasma Concentrations after 192-Hour High Dose Epidural Ropivacaine Infusion in a Pediatric Patient without Side Effects |
| title_fullStr | Ropivacaine Plasma Concentrations after 192-Hour High Dose Epidural Ropivacaine Infusion in a Pediatric Patient without Side Effects |
| title_full_unstemmed | Ropivacaine Plasma Concentrations after 192-Hour High Dose Epidural Ropivacaine Infusion in a Pediatric Patient without Side Effects |
| title_short | Ropivacaine Plasma Concentrations after 192-Hour High Dose Epidural Ropivacaine Infusion in a Pediatric Patient without Side Effects |
| title_sort | ropivacaine plasma concentrations after 192 hour high dose epidural ropivacaine infusion in a pediatric patient without side effects |
| url | http://dx.doi.org/10.1155/2018/9150980 |
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