Cross-tissue MiRNA profiling of extracellular vesicles and PBMCs from amyotrophic lateral sclerosis patients

Cross-tissue MiRNA profiling of extracellular vesicles and PBMCs from amyotrophic lateral sclerosis patients

Abstract RNA-mediated toxicity, which can be controlled by alteration of gene expression, is considered a key event in Amyotrophic Lateral Sclerosis (ALS). Transcriptomic deregulation of miRNAs expression can spread via “horizontal” RNA transfer through extracellular vesicles (EVs) to act in conjunc...

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Main Authors: Francesca Dragoni, Rosalinda Di Gerlando, Luca Diamanti, Bartolo Rizzo, Matteo Bordoni, Eveljn Scarian, Camilla Viola, Giovanni Cerchia, Susanna Zucca, Orietta Pansarasa, Stella Gagliardi
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
ALS
MiRNA
Extracellular vesicles
PBMCs
Biomarkers
Online Access:https://doi.org/10.1038/s41598-025-99206-2
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