Preclinical research models for endometrial cancer: development and selection of animal models

Endometrial cancer (EC) is the most common gynecological malignancy in developed countries, with rising incidence in recent years. Experimental animal models are crucial for studying the pathogenesis, advancing diagnostic methods, and developing new treatments. We review five main EC animal models....

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Main Authors: Yang Xue, Wei Shi, Bing Lun, Meilin Kan, Mengling Jia, Yuelin Wu, Li Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1512616/full
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author Yang Xue
Wei Shi
Bing Lun
Meilin Kan
Mengling Jia
Yuelin Wu
Li Yang
Li Yang
author_facet Yang Xue
Wei Shi
Bing Lun
Meilin Kan
Mengling Jia
Yuelin Wu
Li Yang
Li Yang
author_sort Yang Xue
collection DOAJ
description Endometrial cancer (EC) is the most common gynecological malignancy in developed countries, with rising incidence in recent years. Experimental animal models are crucial for studying the pathogenesis, advancing diagnostic methods, and developing new treatments. We review five main EC animal models. The use of spontaneous and chemically-induced models has decreased, with transgenic mouse and xenograft models becoming the most widely used. These models better simulate tumor molecular mechanisms and treatments, with the organoid-based patient-derived xenograft model (O-PDX) showing great promise in drug screening and personalized therapy. The application of humanized models remains limited due to technical challenges and high costs. In this review, we highlight the strengths and limitations of each model to guide researchers in their selection.
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institution Kabale University
issn 2234-943X
language English
publishDate 2025-02-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Oncology
spelling doaj-art-06bf5a8390554641a79532e2460a6df02025-02-05T05:17:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15126161512616Preclinical research models for endometrial cancer: development and selection of animal modelsYang Xue0Wei Shi1Bing Lun2Meilin Kan3Mengling Jia4Yuelin Wu5Li Yang6Li Yang7Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaZhengzhou Key Laboratory of Endometrial Disease Prevention and Treatment, Zhengzhou, ChinaEndometrial cancer (EC) is the most common gynecological malignancy in developed countries, with rising incidence in recent years. Experimental animal models are crucial for studying the pathogenesis, advancing diagnostic methods, and developing new treatments. We review five main EC animal models. The use of spontaneous and chemically-induced models has decreased, with transgenic mouse and xenograft models becoming the most widely used. These models better simulate tumor molecular mechanisms and treatments, with the organoid-based patient-derived xenograft model (O-PDX) showing great promise in drug screening and personalized therapy. The application of humanized models remains limited due to technical challenges and high costs. In this review, we highlight the strengths and limitations of each model to guide researchers in their selection.https://www.frontiersin.org/articles/10.3389/fonc.2025.1512616/fullendometrial canceranimal modelpreclinical researchpatient-derived xenograft modelhumanized modelorganoid
spellingShingle Yang Xue
Wei Shi
Bing Lun
Meilin Kan
Mengling Jia
Yuelin Wu
Li Yang
Li Yang
Preclinical research models for endometrial cancer: development and selection of animal models
Frontiers in Oncology
endometrial cancer
animal model
preclinical research
patient-derived xenograft model
humanized model
organoid
title Preclinical research models for endometrial cancer: development and selection of animal models
title_full Preclinical research models for endometrial cancer: development and selection of animal models
title_fullStr Preclinical research models for endometrial cancer: development and selection of animal models
title_full_unstemmed Preclinical research models for endometrial cancer: development and selection of animal models
title_short Preclinical research models for endometrial cancer: development and selection of animal models
title_sort preclinical research models for endometrial cancer development and selection of animal models
topic endometrial cancer
animal model
preclinical research
patient-derived xenograft model
humanized model
organoid
url https://www.frontiersin.org/articles/10.3389/fonc.2025.1512616/full
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