Synthetic MRI study of brain volume and subcortical myelin in various Parkinson’s disease motor subtypes
Abstract Alterations in brain volume and subcortical myelin content (MyC) between tremor-dominant (TD) and postural instability and gait difficulty (PIGD) subtypes of Parkinson’s (PD) disease remain unclear. This study investigated whole-brain volume and subcortical myelin content differences among...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01120-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849226473012985856 |
|---|---|
| author | Dongliang Cheng Junyan Wen Nan Ding Zhenpeng Duan Biqing Lin Yunjun Yang Yaozhong Wu Hang Wang Jincheng Ma Jialu Zhang Zhifeng Xu Hai Zhao Yulin Liu Ge Wen |
| author_facet | Dongliang Cheng Junyan Wen Nan Ding Zhenpeng Duan Biqing Lin Yunjun Yang Yaozhong Wu Hang Wang Jincheng Ma Jialu Zhang Zhifeng Xu Hai Zhao Yulin Liu Ge Wen |
| author_sort | Dongliang Cheng |
| collection | DOAJ |
| description | Abstract Alterations in brain volume and subcortical myelin content (MyC) between tremor-dominant (TD) and postural instability and gait difficulty (PIGD) subtypes of Parkinson’s (PD) disease remain unclear. This study investigated whole-brain volume and subcortical myelin content differences among PD motor subtypes using synthetic MRI. Ninety-two PD patients (39 TD and 53 PIGD) and 39 healthy controls were included. ANCOVA identified that PD patients exhibited reduced gray matter, white matter, and MyC, with no distinct atrophy patterns between TD and PIGD. Most subcortical nuclei showed decreased myelin, while PIGD presented more extensive alterations and increased bilateral caudate myelin; TD exhibited asymmetric thalamic myelin changes, with lateralized increases and decreases. Significant MyC differences in the left caudate and right GPi were observed between TD and PIGD. Synthetic MRI-derived parameters provide insights into whole-brain atrophy patterns and dynamic myelin changes in PD, contributing to a deeper understanding of PD subtypes. |
| format | Article |
| id | doaj-art-06be9e2061004f058df52e9b0c9bb430 |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-06be9e2061004f058df52e9b0c9bb4302025-08-24T11:14:44ZengNature Portfolionpj Parkinson's Disease2373-80572025-08-0111111010.1038/s41531-025-01120-xSynthetic MRI study of brain volume and subcortical myelin in various Parkinson’s disease motor subtypesDongliang Cheng0Junyan Wen1Nan Ding2Zhenpeng Duan3Biqing Lin4Yunjun Yang5Yaozhong Wu6Hang Wang7Jincheng Ma8Jialu Zhang9Zhifeng Xu10Hai Zhao11Yulin Liu12Ge Wen13Medical Imaging Center, Nanfang Hospital, Southern Medical UniversityMedical Imaging Center, Nanfang Hospital, Southern Medical UniversityDepartment of Neurology, The First People’s Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and TechnologyDepartment of Neurology, The First People’s Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and TechnologyDepartment of Neurology, The First People’s Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and TechnologyDepartment of Radiology, The First People’s Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and TechnologyDepartment of Radiology, The First People’s Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and TechnologyDepartment of Radiology, The First People’s Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and TechnologyDepartment of Radiology, The First People’s Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and TechnologyMR Research, GE HealthcareDepartment of Radiology, The First People’s Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and TechnologyDepartment of Radiology, The First People’s Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and TechnologyDepartment of Rehabilitation Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityMedical Imaging Center, Nanfang Hospital, Southern Medical UniversityAbstract Alterations in brain volume and subcortical myelin content (MyC) between tremor-dominant (TD) and postural instability and gait difficulty (PIGD) subtypes of Parkinson’s (PD) disease remain unclear. This study investigated whole-brain volume and subcortical myelin content differences among PD motor subtypes using synthetic MRI. Ninety-two PD patients (39 TD and 53 PIGD) and 39 healthy controls were included. ANCOVA identified that PD patients exhibited reduced gray matter, white matter, and MyC, with no distinct atrophy patterns between TD and PIGD. Most subcortical nuclei showed decreased myelin, while PIGD presented more extensive alterations and increased bilateral caudate myelin; TD exhibited asymmetric thalamic myelin changes, with lateralized increases and decreases. Significant MyC differences in the left caudate and right GPi were observed between TD and PIGD. Synthetic MRI-derived parameters provide insights into whole-brain atrophy patterns and dynamic myelin changes in PD, contributing to a deeper understanding of PD subtypes.https://doi.org/10.1038/s41531-025-01120-x |
| spellingShingle | Dongliang Cheng Junyan Wen Nan Ding Zhenpeng Duan Biqing Lin Yunjun Yang Yaozhong Wu Hang Wang Jincheng Ma Jialu Zhang Zhifeng Xu Hai Zhao Yulin Liu Ge Wen Synthetic MRI study of brain volume and subcortical myelin in various Parkinson’s disease motor subtypes npj Parkinson's Disease |
| title | Synthetic MRI study of brain volume and subcortical myelin in various Parkinson’s disease motor subtypes |
| title_full | Synthetic MRI study of brain volume and subcortical myelin in various Parkinson’s disease motor subtypes |
| title_fullStr | Synthetic MRI study of brain volume and subcortical myelin in various Parkinson’s disease motor subtypes |
| title_full_unstemmed | Synthetic MRI study of brain volume and subcortical myelin in various Parkinson’s disease motor subtypes |
| title_short | Synthetic MRI study of brain volume and subcortical myelin in various Parkinson’s disease motor subtypes |
| title_sort | synthetic mri study of brain volume and subcortical myelin in various parkinson s disease motor subtypes |
| url | https://doi.org/10.1038/s41531-025-01120-x |
| work_keys_str_mv | AT dongliangcheng syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT junyanwen syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT nanding syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT zhenpengduan syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT biqinglin syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT yunjunyang syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT yaozhongwu syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT hangwang syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT jinchengma syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT jialuzhang syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT zhifengxu syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT haizhao syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT yulinliu syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes AT gewen syntheticmristudyofbrainvolumeandsubcorticalmyelininvariousparkinsonsdiseasemotorsubtypes |