A clinical case of repeat use of PARP inhibitors in a patient with <i>mBRCA</i>-associated ovarian cancer
Backgraound. High-grade serous ovarian carcinoma (HGSOC) is the most common type of ovarian cancer. The prevalence of BRCA1/2 germline mutations is the highest in HGSOC. patients with germline BRCA gene mutations are more likely to respond to platinum-based chemotherapy. Clinical trials demonstrate...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2022-09-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/2240 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849700015682879488 |
|---|---|
| author | A. B. Villert I. A. Kolomiets Y. A. Fesik A. A. Ivanova N. V. Yunusova О. N. Churuksaeva |
| author_facet | A. B. Villert I. A. Kolomiets Y. A. Fesik A. A. Ivanova N. V. Yunusova О. N. Churuksaeva |
| author_sort | A. B. Villert |
| collection | DOAJ |
| description | Backgraound. High-grade serous ovarian carcinoma (HGSOC) is the most common type of ovarian cancer. The prevalence of BRCA1/2 germline mutations is the highest in HGSOC. patients with germline BRCA gene mutations are more likely to respond to platinum-based chemotherapy. Clinical trials demonstrate the effectiveness of PARP inhibitors in the treatment of BRCA-associated ovarian cancer. Re-administration of PARP inhibitors after response to platinum-based chemotherapy demonstrates an increase in progression-free survival rates regardless of BRCA status. it is important for understanding the development of molecular mechanisms of resistance to platinum drugs and PARP inhibitors, as well as for developing new treatment strategies and tools to overcome resistance. Case description. This clinical case of BRCA-associated hereditary ovarian cancer demonstrates the efficacy and good tolerability of PARP inhibitor maintenance therapy following the treatment of the first relapse, as well as the efficacy of re-administration of PARP inhibitors following the treatment of the second relapse. The short-course of re-treatment with PARP inhibitors was accompanied by the development of multidrug resistance. the overall survival time was 112 months. Conclusion. The presence of mutations in BRCA1/2 genes is a promising justification for the administration of maintenance therapy with PARP inhibitors. Re-administration of PARP inhibitor maintenance therapy for relapsed ovarian cancer is currently being considered as a possible therapeutic option. deciphering the molecular mechanisms of resistance to PARP inhibitors is of paramount importance for the development of new treatment strategies and tools to overcome chemoresistance, re-sensitization of the tumor to platinum-based drugs or PARP inhibitors. |
| format | Article |
| id | doaj-art-06ba19d2f0674e648dc01c8629529055 |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2022-09-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-06ba19d2f0674e648dc01c86295290552025-08-20T03:18:24ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682022-09-0121415616410.21294/1814-4861-2022-21-4-156-1641024A clinical case of repeat use of PARP inhibitors in a patient with <i>mBRCA</i>-associated ovarian cancerA. B. Villert0I. A. Kolomiets1Y. A. Fesik2A. A. Ivanova3N. V. Yunusova4О. N. Churuksaeva5Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University of The Ministry of Health of RussiaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University of The Ministry of Health of RussiaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesBackgraound. High-grade serous ovarian carcinoma (HGSOC) is the most common type of ovarian cancer. The prevalence of BRCA1/2 germline mutations is the highest in HGSOC. patients with germline BRCA gene mutations are more likely to respond to platinum-based chemotherapy. Clinical trials demonstrate the effectiveness of PARP inhibitors in the treatment of BRCA-associated ovarian cancer. Re-administration of PARP inhibitors after response to platinum-based chemotherapy demonstrates an increase in progression-free survival rates regardless of BRCA status. it is important for understanding the development of molecular mechanisms of resistance to platinum drugs and PARP inhibitors, as well as for developing new treatment strategies and tools to overcome resistance. Case description. This clinical case of BRCA-associated hereditary ovarian cancer demonstrates the efficacy and good tolerability of PARP inhibitor maintenance therapy following the treatment of the first relapse, as well as the efficacy of re-administration of PARP inhibitors following the treatment of the second relapse. The short-course of re-treatment with PARP inhibitors was accompanied by the development of multidrug resistance. the overall survival time was 112 months. Conclusion. The presence of mutations in BRCA1/2 genes is a promising justification for the administration of maintenance therapy with PARP inhibitors. Re-administration of PARP inhibitor maintenance therapy for relapsed ovarian cancer is currently being considered as a possible therapeutic option. deciphering the molecular mechanisms of resistance to PARP inhibitors is of paramount importance for the development of new treatment strategies and tools to overcome chemoresistance, re-sensitization of the tumor to platinum-based drugs or PARP inhibitors.https://www.siboncoj.ru/jour/article/view/2240ovarian cancerplatinum-sensitive relapse<i>brca1</i><i>brca2</i> mutationre-administration of parp inhibitor therapy |
| spellingShingle | A. B. Villert I. A. Kolomiets Y. A. Fesik A. A. Ivanova N. V. Yunusova О. N. Churuksaeva A clinical case of repeat use of PARP inhibitors in a patient with <i>mBRCA</i>-associated ovarian cancer Сибирский онкологический журнал ovarian cancer platinum-sensitive relapse <i>brca1</i> <i>brca2</i> mutation re-administration of parp inhibitor therapy |
| title | A clinical case of repeat use of PARP inhibitors in a patient with <i>mBRCA</i>-associated ovarian cancer |
| title_full | A clinical case of repeat use of PARP inhibitors in a patient with <i>mBRCA</i>-associated ovarian cancer |
| title_fullStr | A clinical case of repeat use of PARP inhibitors in a patient with <i>mBRCA</i>-associated ovarian cancer |
| title_full_unstemmed | A clinical case of repeat use of PARP inhibitors in a patient with <i>mBRCA</i>-associated ovarian cancer |
| title_short | A clinical case of repeat use of PARP inhibitors in a patient with <i>mBRCA</i>-associated ovarian cancer |
| title_sort | clinical case of repeat use of parp inhibitors in a patient with i mbrca i associated ovarian cancer |
| topic | ovarian cancer platinum-sensitive relapse <i>brca1</i> <i>brca2</i> mutation re-administration of parp inhibitor therapy |
| url | https://www.siboncoj.ru/jour/article/view/2240 |
| work_keys_str_mv | AT abvillert aclinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer AT iakolomiets aclinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer AT yafesik aclinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer AT aaivanova aclinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer AT nvyunusova aclinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer AT onchuruksaeva aclinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer AT abvillert clinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer AT iakolomiets clinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer AT yafesik clinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer AT aaivanova clinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer AT nvyunusova clinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer AT onchuruksaeva clinicalcaseofrepeatuseofparpinhibitorsinapatientwithimbrcaiassociatedovariancancer |