The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating the interactions between lifestyle and health in Manitoba, Canada
Introduction Lifestyle factors, such as diet, physical activity and sleep, are associated with the development of many chronic diseases. The objective of The Manitoba Personalized Lifestyle Research study is to understand how these lifestyle factors interact with each other and with other factors, s...
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BMJ Publishing Group
2019-10-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/10/e023318.full |
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| author | Navdeep Tangri Dylan Mackay Rebecca C Mollard Matthew Granger Sharon Bruce Heather Blewett Jared Carlberg Todd Duhamel Peter Eck Patrick Faucher Naomi C Hamm Ehsan Khafipour Diana McMillan Semone Myrie Amir Ravandi Meghan Azad Peter JH Jones |
| author_facet | Navdeep Tangri Dylan Mackay Rebecca C Mollard Matthew Granger Sharon Bruce Heather Blewett Jared Carlberg Todd Duhamel Peter Eck Patrick Faucher Naomi C Hamm Ehsan Khafipour Diana McMillan Semone Myrie Amir Ravandi Meghan Azad Peter JH Jones |
| author_sort | Navdeep Tangri |
| collection | DOAJ |
| description | Introduction Lifestyle factors, such as diet, physical activity and sleep, are associated with the development of many chronic diseases. The objective of The Manitoba Personalized Lifestyle Research study is to understand how these lifestyle factors interact with each other and with other factors, such as an individual’s genetics and gut microbiome, to influence health.Methods An observational study of adults, with extensive phenotyping by objective health and lifestyle assessments, and retrospective assessment of early life experiences, with retrospective and prospective utilisation of secondary data from administrative health records.Study population A planned non-random convenience sample of 840 Manitobans aged 30–46 recruited from the general population, stratified by sex (equal men and women), body mass index (BMI; 60% of participants with a BMI>25 kg/m2) and geography (25% from rural areas). These stratifications were selected based on Manitoba demographics.Measurements Lifestyle factors assessed will include dietary pattern, physical activity, cardiovascular fitness, and sleep. Factors such as medical history, socioeconomic status, alcohol and tobacco consumption, cognition, stress, anxiety, and early life experiences will also be documented. A maternal survey will be performed. Body composition and bone density will be measured by dual energy X-ray absorptiometry. Blood pressure, pulse wave velocity, and augmentation index will be measured on two consecutive days. Chronic disease risk biomarkers will be measured in blood and urine samples. DNA will be extracted for genetic analysis. A faecal sample will be collected for microbiome analysis. Participants may provide their Manitoba personal health information number to link their study data with administrative health records.Ethics and dissemination Ethics approval has been obtained from the University of Manitoba Health Research Ethics Board (protocol # HS18951; 05/01/2016). Data analysis, release of results and publication of manuscripts are scheduled to start in early 2019. Additional information at www.TMPLR.ca.Trial registration number NCT03674957; Pre-results. |
| format | Article |
| id | doaj-art-06b88cc8f1cc41f59516db6fe3a30eeb |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-06b88cc8f1cc41f59516db6fe3a30eeb2025-08-20T01:59:10ZengBMJ Publishing GroupBMJ Open2044-60552019-10-0191010.1136/bmjopen-2018-023318The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating the interactions between lifestyle and health in Manitoba, CanadaNavdeep Tangri0Dylan Mackay1Rebecca C Mollard2Matthew Granger3Sharon Bruce4Heather Blewett5Jared Carlberg6Todd Duhamel7Peter Eck8Patrick Faucher9Naomi C Hamm10Ehsan Khafipour11Diana McMillan12Semone Myrie13Amir Ravandi14Meghan Azad15Peter JH Jones16Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada1 Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada3 Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada3 Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada1 Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada3 Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada5 Department of Agribusiness and Agricultural Economics, University of Manitoba, Winnipeg, Manitoba, CanadaFaculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, Manitoba, Canada3 Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada2 George and Fay Yee Centre for Healthcare Innovation, Winnipeg, Manitoba, CanadaDepartment of Community Health Sciences, University of Manitoba, Max Rady College of Medicine, Winnipeg, Manitoba, Canada9 Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, Canada6 Health, Leisure and Human Performance Research Institute, University of Manitoba, Winnipeg, Manitoba, Canada3 Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada7 Institute of Cardiovascular Sciences, St. Boniface General Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada8 Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada3 Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, CanadaIntroduction Lifestyle factors, such as diet, physical activity and sleep, are associated with the development of many chronic diseases. The objective of The Manitoba Personalized Lifestyle Research study is to understand how these lifestyle factors interact with each other and with other factors, such as an individual’s genetics and gut microbiome, to influence health.Methods An observational study of adults, with extensive phenotyping by objective health and lifestyle assessments, and retrospective assessment of early life experiences, with retrospective and prospective utilisation of secondary data from administrative health records.Study population A planned non-random convenience sample of 840 Manitobans aged 30–46 recruited from the general population, stratified by sex (equal men and women), body mass index (BMI; 60% of participants with a BMI>25 kg/m2) and geography (25% from rural areas). These stratifications were selected based on Manitoba demographics.Measurements Lifestyle factors assessed will include dietary pattern, physical activity, cardiovascular fitness, and sleep. Factors such as medical history, socioeconomic status, alcohol and tobacco consumption, cognition, stress, anxiety, and early life experiences will also be documented. A maternal survey will be performed. Body composition and bone density will be measured by dual energy X-ray absorptiometry. Blood pressure, pulse wave velocity, and augmentation index will be measured on two consecutive days. Chronic disease risk biomarkers will be measured in blood and urine samples. DNA will be extracted for genetic analysis. A faecal sample will be collected for microbiome analysis. Participants may provide their Manitoba personal health information number to link their study data with administrative health records.Ethics and dissemination Ethics approval has been obtained from the University of Manitoba Health Research Ethics Board (protocol # HS18951; 05/01/2016). Data analysis, release of results and publication of manuscripts are scheduled to start in early 2019. Additional information at www.TMPLR.ca.Trial registration number NCT03674957; Pre-results.https://bmjopen.bmj.com/content/9/10/e023318.full |
| spellingShingle | Navdeep Tangri Dylan Mackay Rebecca C Mollard Matthew Granger Sharon Bruce Heather Blewett Jared Carlberg Todd Duhamel Peter Eck Patrick Faucher Naomi C Hamm Ehsan Khafipour Diana McMillan Semone Myrie Amir Ravandi Meghan Azad Peter JH Jones The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating the interactions between lifestyle and health in Manitoba, Canada BMJ Open |
| title | The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating the interactions between lifestyle and health in Manitoba, Canada |
| title_full | The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating the interactions between lifestyle and health in Manitoba, Canada |
| title_fullStr | The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating the interactions between lifestyle and health in Manitoba, Canada |
| title_full_unstemmed | The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating the interactions between lifestyle and health in Manitoba, Canada |
| title_short | The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating the interactions between lifestyle and health in Manitoba, Canada |
| title_sort | manitoba personalized lifestyle research tmplr study protocol a multicentre bidirectional observational cohort study with administrative health record linkage investigating the interactions between lifestyle and health in manitoba canada |
| url | https://bmjopen.bmj.com/content/9/10/e023318.full |
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