Biological Treatments: New Weapons in the Management of Monogenic Autoinflammatory Disorders
Treatment of monogenic autoinflammatory disorders, an expanding group of hereditary diseases characterized by apparently unprovoked recurrent episodes of inflammation, without high-titre autoantibodies or antigen-specific T cells, has been revolutionized by the discovery that several of these condit...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/939847 |
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| _version_ | 1850233868341215232 |
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| author | Antonio Vitale Donato Rigante Orso Maria Lucherini Francesco Caso Isabella Muscari Flora Magnotti Maria Giuseppina Brizi Susanna Guerrini Maria Patti Leonardo Punzi Mauro Galeazzi Luca Cantarini |
| author_facet | Antonio Vitale Donato Rigante Orso Maria Lucherini Francesco Caso Isabella Muscari Flora Magnotti Maria Giuseppina Brizi Susanna Guerrini Maria Patti Leonardo Punzi Mauro Galeazzi Luca Cantarini |
| author_sort | Antonio Vitale |
| collection | DOAJ |
| description | Treatment of monogenic autoinflammatory disorders, an expanding group of hereditary diseases characterized by apparently unprovoked recurrent episodes of inflammation, without high-titre autoantibodies or antigen-specific T cells, has been revolutionized by the discovery that several of these conditions are caused by mutations in proteins involved in the mechanisms of innate immune response, including components of the inflammasome, cytokine receptors, receptor antagonists, and oversecretion of a network of proinflammatory molecules. Aim of this review is to synthesize the current experience and the most recent evidences about the therapeutic approach with biologic drugs in pediatric and adult patients with monogenic autoinflammatory disorders. |
| format | Article |
| id | doaj-art-06b43fea8a5c4944a4e41bf05b646e51 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-06b43fea8a5c4944a4e41bf05b646e512025-08-20T02:02:48ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/939847939847Biological Treatments: New Weapons in the Management of Monogenic Autoinflammatory DisordersAntonio Vitale0Donato Rigante1Orso Maria Lucherini2Francesco Caso3Isabella Muscari4Flora Magnotti5Maria Giuseppina Brizi6Susanna Guerrini7Maria Patti8Leonardo Punzi9Mauro Galeazzi10Luca Cantarini11Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyInstitute of Pediatrics, Università Cattolica Sacro Cuore, Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Rome, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyRheumatology Unit, Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128 Padova, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyInstitute of Pediatrics, Università Cattolica Sacro Cuore, Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Rome, ItalyRheumatology Unit, Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128 Padova, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyTreatment of monogenic autoinflammatory disorders, an expanding group of hereditary diseases characterized by apparently unprovoked recurrent episodes of inflammation, without high-titre autoantibodies or antigen-specific T cells, has been revolutionized by the discovery that several of these conditions are caused by mutations in proteins involved in the mechanisms of innate immune response, including components of the inflammasome, cytokine receptors, receptor antagonists, and oversecretion of a network of proinflammatory molecules. Aim of this review is to synthesize the current experience and the most recent evidences about the therapeutic approach with biologic drugs in pediatric and adult patients with monogenic autoinflammatory disorders.http://dx.doi.org/10.1155/2013/939847 |
| spellingShingle | Antonio Vitale Donato Rigante Orso Maria Lucherini Francesco Caso Isabella Muscari Flora Magnotti Maria Giuseppina Brizi Susanna Guerrini Maria Patti Leonardo Punzi Mauro Galeazzi Luca Cantarini Biological Treatments: New Weapons in the Management of Monogenic Autoinflammatory Disorders Mediators of Inflammation |
| title | Biological Treatments: New Weapons in the Management of Monogenic Autoinflammatory Disorders |
| title_full | Biological Treatments: New Weapons in the Management of Monogenic Autoinflammatory Disorders |
| title_fullStr | Biological Treatments: New Weapons in the Management of Monogenic Autoinflammatory Disorders |
| title_full_unstemmed | Biological Treatments: New Weapons in the Management of Monogenic Autoinflammatory Disorders |
| title_short | Biological Treatments: New Weapons in the Management of Monogenic Autoinflammatory Disorders |
| title_sort | biological treatments new weapons in the management of monogenic autoinflammatory disorders |
| url | http://dx.doi.org/10.1155/2013/939847 |
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