Surgical treatment of a patient with multiple endocrine neoplasia type 2A
The diagnosis and treatment of multiple endocrine neoplasia type 2A syndrome or Sipple’s syndrome, as well as other endocrine hereditary syndromes, presents certain difficulties for several reasons. One of them is the rarity of this pathology and, as a result, the lack of awareness of physicians. In...
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| Format: | Article |
| Language: | Russian |
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Pavlov First Saint Petersburg State Medical University
2020-11-01
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| Series: | Вестник хирургии имени И.И. Грекова |
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| Online Access: | https://www.vestnik-grekova.ru/jour/article/view/1522 |
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| _version_ | 1849771860587184128 |
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| author | T. A. Britvin E. V. Bondarenko A. V. Krivosheev O. A. Nechaeva T. S. Tamazyan D. V. Podrez L. E. Gurevich P. A. Korosteleva |
| author_facet | T. A. Britvin E. V. Bondarenko A. V. Krivosheev O. A. Nechaeva T. S. Tamazyan D. V. Podrez L. E. Gurevich P. A. Korosteleva |
| author_sort | T. A. Britvin |
| collection | DOAJ |
| description | The diagnosis and treatment of multiple endocrine neoplasia type 2A syndrome or Sipple’s syndrome, as well as other endocrine hereditary syndromes, presents certain difficulties for several reasons. One of them is the rarity of this pathology and, as a result, the lack of awareness of physicians. In addition, the diagnosis requires a comprehensive examination and a high level of clinical, laboratory, radiation and morphological diagnostics. And finally, surgical treatment, which is essentially the only method, involves an individual approach to each patient. We present the clinical case of Sipple's syndrome in a 39-year-old man. The diagnosis was carried out of medical history, clinical examination, laboratory tests (24-hour urine excretion of metanephrines and normetanephrines; serum calcium, calcitonin and parathyroid hormone levels), neck ultrasound and abdominal CT scan and was confirmed by histopathological examination and genetic testing for RET mutation. The achievement of the endpoint in the form of normalization of blood pressure and the absence of adrenal insufficiency was due to radical surgical treatment. |
| format | Article |
| id | doaj-art-06b1fa37618c4e5da5c1fe2fcfb04ba4 |
| institution | DOAJ |
| issn | 0042-4625 |
| language | Russian |
| publishDate | 2020-11-01 |
| publisher | Pavlov First Saint Petersburg State Medical University |
| record_format | Article |
| series | Вестник хирургии имени И.И. Грекова |
| spelling | doaj-art-06b1fa37618c4e5da5c1fe2fcfb04ba42025-08-20T03:02:29ZrusPavlov First Saint Petersburg State Medical UniversityВестник хирургии имени И.И. Грекова0042-46252020-11-011794798610.24884/0042-4625-2020-179-4-79-861163Surgical treatment of a patient with multiple endocrine neoplasia type 2AT. A. Britvin0E. V. Bondarenko1A. V. Krivosheev2O. A. Nechaeva3T. S. Tamazyan4D. V. Podrez5L. E. Gurevich6P. A. Korosteleva7Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)Moscow Regional Research and Clinical Institute (MONIKI)The diagnosis and treatment of multiple endocrine neoplasia type 2A syndrome or Sipple’s syndrome, as well as other endocrine hereditary syndromes, presents certain difficulties for several reasons. One of them is the rarity of this pathology and, as a result, the lack of awareness of physicians. In addition, the diagnosis requires a comprehensive examination and a high level of clinical, laboratory, radiation and morphological diagnostics. And finally, surgical treatment, which is essentially the only method, involves an individual approach to each patient. We present the clinical case of Sipple's syndrome in a 39-year-old man. The diagnosis was carried out of medical history, clinical examination, laboratory tests (24-hour urine excretion of metanephrines and normetanephrines; serum calcium, calcitonin and parathyroid hormone levels), neck ultrasound and abdominal CT scan and was confirmed by histopathological examination and genetic testing for RET mutation. The achievement of the endpoint in the form of normalization of blood pressure and the absence of adrenal insufficiency was due to radical surgical treatment.https://www.vestnik-grekova.ru/jour/article/view/1522sipple’s syndrome, medullary thyroid carcinoma, pheochromocytoma, ret-gene, surgical treatment |
| spellingShingle | T. A. Britvin E. V. Bondarenko A. V. Krivosheev O. A. Nechaeva T. S. Tamazyan D. V. Podrez L. E. Gurevich P. A. Korosteleva Surgical treatment of a patient with multiple endocrine neoplasia type 2A Вестник хирургии имени И.И. Грекова sipple’s syndrome, medullary thyroid carcinoma, pheochromocytoma, ret-gene, surgical treatment |
| title | Surgical treatment of a patient with multiple endocrine neoplasia type 2A |
| title_full | Surgical treatment of a patient with multiple endocrine neoplasia type 2A |
| title_fullStr | Surgical treatment of a patient with multiple endocrine neoplasia type 2A |
| title_full_unstemmed | Surgical treatment of a patient with multiple endocrine neoplasia type 2A |
| title_short | Surgical treatment of a patient with multiple endocrine neoplasia type 2A |
| title_sort | surgical treatment of a patient with multiple endocrine neoplasia type 2a |
| topic | sipple’s syndrome, medullary thyroid carcinoma, pheochromocytoma, ret-gene, surgical treatment |
| url | https://www.vestnik-grekova.ru/jour/article/view/1522 |
| work_keys_str_mv | AT tabritvin surgicaltreatmentofapatientwithmultipleendocrineneoplasiatype2a AT evbondarenko surgicaltreatmentofapatientwithmultipleendocrineneoplasiatype2a AT avkrivosheev surgicaltreatmentofapatientwithmultipleendocrineneoplasiatype2a AT oanechaeva surgicaltreatmentofapatientwithmultipleendocrineneoplasiatype2a AT tstamazyan surgicaltreatmentofapatientwithmultipleendocrineneoplasiatype2a AT dvpodrez surgicaltreatmentofapatientwithmultipleendocrineneoplasiatype2a AT legurevich surgicaltreatmentofapatientwithmultipleendocrineneoplasiatype2a AT pakorosteleva surgicaltreatmentofapatientwithmultipleendocrineneoplasiatype2a |