Inhibitior of Bcl6 by FX1 protects DSS induced colitis mice through anti-inflammatory effects

Inhibitior of Bcl6 by FX1 protects DSS induced colitis mice through anti-inflammatory effects

IntroductionInflammatory bowel disease (IBD) is a complex immune-mediated condition, and biologics are the most commonly used drugs for its treatment. However, there are still cases of ineffective treatment. B-cell lymphoma 6 (Bcl6), a transcriptional suppressor, is known to have regulatory effects...

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Main Authors: Ruixian Liu, Zhe Zhang, Chuan Zhou, Binbin Wang, Muhan Zhang, Yaxing Sun, Yao Yao, Yanru Zhang, Yijia He, Junzhi Yu, Yimeng Xia, Yan Liu, Shiyang Ning, Baisui Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
BCL6
IBD
pro-inflammatory cytokines
macrophage
tight junction proteins (TJPs)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558845/full
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