A rich conformational palette underlies human CaV2.1-channel availability

A rich conformational palette underlies human CaV2.1-channel availability

Abstract Depolarization-evoked opening of CaV2.1 (P/Q-type) Ca2+-channels triggers neurotransmitter release, while voltage-dependent inactivation (VDI) limits channel availability to open, contributing to synaptic plasticity. The mechanism of CaV2.1 response to voltage is unclear. Using voltage-clam...

Full description

Saved in:
Bibliographic Details
Main Authors: Kaiqian Wang, Michelle Nilsson, Marina Angelini, Riccardo Olcese, Fredrik Elinder, Antonios Pantazis
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58884-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items