Formation and Regulation of Mitochondrial Membranes
Mitochondrial membrane phospholipids are essential for the mitochondrial architecture, the activity of respiratory proteins, and the transport of proteins into the mitochondria. The accumulation of phospholipids within mitochondria depends on a coordinate synthesis, degradation, and trafficking of p...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2014/709828 |
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| _version_ | 1850230978013822976 |
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| author | Laila Cigana Schenkel Marica Bakovic |
| author_facet | Laila Cigana Schenkel Marica Bakovic |
| author_sort | Laila Cigana Schenkel |
| collection | DOAJ |
| description | Mitochondrial membrane phospholipids are essential for the mitochondrial architecture, the activity of respiratory proteins, and the transport of proteins into the mitochondria. The accumulation of phospholipids within mitochondria depends on a coordinate synthesis, degradation, and trafficking of phospholipids between the endoplasmic reticulum (ER) and mitochondria as well as intramitochondrial lipid trafficking. Several studies highlight the contribution of dietary fatty acids to the remodeling of phospholipids and mitochondrial membrane homeostasis. Understanding the role of phospholipids in the mitochondrial membrane and their metabolism will shed light on the molecular mechanisms involved in the regulation of mitochondrial function and in the mitochondrial-related diseases. |
| format | Article |
| id | doaj-art-069e3412badf4ee18f43c828db765e68 |
| institution | OA Journals |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-069e3412badf4ee18f43c828db765e682025-08-20T02:03:42ZengWileyInternational Journal of Cell Biology1687-88761687-88842014-01-01201410.1155/2014/709828709828Formation and Regulation of Mitochondrial MembranesLaila Cigana Schenkel0Marica Bakovic1Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, CanadaDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, CanadaMitochondrial membrane phospholipids are essential for the mitochondrial architecture, the activity of respiratory proteins, and the transport of proteins into the mitochondria. The accumulation of phospholipids within mitochondria depends on a coordinate synthesis, degradation, and trafficking of phospholipids between the endoplasmic reticulum (ER) and mitochondria as well as intramitochondrial lipid trafficking. Several studies highlight the contribution of dietary fatty acids to the remodeling of phospholipids and mitochondrial membrane homeostasis. Understanding the role of phospholipids in the mitochondrial membrane and their metabolism will shed light on the molecular mechanisms involved in the regulation of mitochondrial function and in the mitochondrial-related diseases.http://dx.doi.org/10.1155/2014/709828 |
| spellingShingle | Laila Cigana Schenkel Marica Bakovic Formation and Regulation of Mitochondrial Membranes International Journal of Cell Biology |
| title | Formation and Regulation of Mitochondrial Membranes |
| title_full | Formation and Regulation of Mitochondrial Membranes |
| title_fullStr | Formation and Regulation of Mitochondrial Membranes |
| title_full_unstemmed | Formation and Regulation of Mitochondrial Membranes |
| title_short | Formation and Regulation of Mitochondrial Membranes |
| title_sort | formation and regulation of mitochondrial membranes |
| url | http://dx.doi.org/10.1155/2014/709828 |
| work_keys_str_mv | AT lailaciganaschenkel formationandregulationofmitochondrialmembranes AT maricabakovic formationandregulationofmitochondrialmembranes |