Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions
Uncontrolled hemorrhage remains the leading cause of death in clinical and emergency care, posing a major threat to human life. To achieve effective bleeding control, many hemostatic materials have emerged. Among them, nature-derived biopolymers occupy an important position due to the excellent inhe...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24005267 |
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| author | Chen-Yu Zou Chen Han Fei Xing Yan-Lin Jiang Ming Xiong Jesse Li-Ling Hui-Qi Xie |
| author_facet | Chen-Yu Zou Chen Han Fei Xing Yan-Lin Jiang Ming Xiong Jesse Li-Ling Hui-Qi Xie |
| author_sort | Chen-Yu Zou |
| collection | DOAJ |
| description | Uncontrolled hemorrhage remains the leading cause of death in clinical and emergency care, posing a major threat to human life. To achieve effective bleeding control, many hemostatic materials have emerged. Among them, nature-derived biopolymers occupy an important position due to the excellent inherent biocompatibility, biodegradability and bioactivity. Additionally, sponges have been widely used in clinical and daily life because of their rapid blood absorption. Therefore, we provide the overview focusing on the latest advances and smart designs of biopolymer-based hemostatic sponge. Starting from the component, the applications of polysaccharide and polypeptide in hemostasis are systematically introduced, and the unique bioactivities such as antibacterial, antioxidant and immunomodulation are also concerned. From the perspective of sponge structure, different preparation processes can obtain unique physical properties and structures, which will affect the material properties such as hemostasis, antibacterial and tissue repair. Notably, as development frontier, the multi-functions of hemostatic materials is summarized, mainly including enhanced coagulation, antibacterial, avoiding tumor recurrence, promoting tissue repair, and hemorrhage monitoring. Finally, the challenges facing the development of biopolymer-based hemostatic sponges are emphasized, and future directions for in vivo biosafety, emerging materials, multiple application scenarios and translational research are proposed. |
| format | Article |
| id | doaj-art-06950e58587342acbb552e4fb52409fe |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-06950e58587342acbb552e4fb52409fe2025-01-26T05:04:26ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-0145459478Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functionsChen-Yu Zou0Chen Han1Fei Xing2Yan-Lin Jiang3Ming Xiong4Jesse Li-Ling5Hui-Qi Xie6Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China; Frontier Medical Center, Tianfu Jincheng Laboratory, 610212, Chengdu, Sichuan, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China; Frontier Medical Center, Tianfu Jincheng Laboratory, 610212, Chengdu, Sichuan, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China; Department of Pediatric Surgery, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China; Frontier Medical Center, Tianfu Jincheng Laboratory, 610212, Chengdu, Sichuan, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China; Department of Medical Genetics, West China Second Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China; Frontier Medical Center, Tianfu Jincheng Laboratory, 610212, Chengdu, Sichuan, PR China; Corresponding author. Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, PR China.Uncontrolled hemorrhage remains the leading cause of death in clinical and emergency care, posing a major threat to human life. To achieve effective bleeding control, many hemostatic materials have emerged. Among them, nature-derived biopolymers occupy an important position due to the excellent inherent biocompatibility, biodegradability and bioactivity. Additionally, sponges have been widely used in clinical and daily life because of their rapid blood absorption. Therefore, we provide the overview focusing on the latest advances and smart designs of biopolymer-based hemostatic sponge. Starting from the component, the applications of polysaccharide and polypeptide in hemostasis are systematically introduced, and the unique bioactivities such as antibacterial, antioxidant and immunomodulation are also concerned. From the perspective of sponge structure, different preparation processes can obtain unique physical properties and structures, which will affect the material properties such as hemostasis, antibacterial and tissue repair. Notably, as development frontier, the multi-functions of hemostatic materials is summarized, mainly including enhanced coagulation, antibacterial, avoiding tumor recurrence, promoting tissue repair, and hemorrhage monitoring. Finally, the challenges facing the development of biopolymer-based hemostatic sponges are emphasized, and future directions for in vivo biosafety, emerging materials, multiple application scenarios and translational research are proposed.http://www.sciencedirect.com/science/article/pii/S2452199X24005267BiopolymerHemostatic spongesHemostasisMultiple functionsComponentStructure |
| spellingShingle | Chen-Yu Zou Chen Han Fei Xing Yan-Lin Jiang Ming Xiong Jesse Li-Ling Hui-Qi Xie Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions Bioactive Materials Biopolymer Hemostatic sponges Hemostasis Multiple functions Component Structure |
| title | Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions |
| title_full | Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions |
| title_fullStr | Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions |
| title_full_unstemmed | Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions |
| title_short | Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions |
| title_sort | smart design in biopolymer based hemostatic sponges from hemostasis to multiple functions |
| topic | Biopolymer Hemostatic sponges Hemostasis Multiple functions Component Structure |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24005267 |
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